ArticleFrontiers in physiology2025
Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Serum Behavior of NT-3 and VEGFβ, Two Unstudied Growth Factors in Patients with Diabetes Mellitus and End-Stage Renal Disease.Journal of clinical medicine · 2025Article
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5 authors.
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Abstract
Objective: We sought to measure skeletal muscle microvascular hemodynamic responses in Sprague Dawley (SD) and Zucker Diabetic Sprague Dawley (ZDSD) rat model of type 2 diabetes (T2D) at rest and during a hyperinsulinemic-euglycemic clamp under resting conditions and during acute changes in local tissue oxygen concentration [(O Methods: Male SD and ZDSD rats were fed a high-fat diet, transitioned to a high-fat high-sugar diet from 16-19 weeks old to induce T2D in the ZDSD strain, then returned to the high-fat diet until intravital video microscopy (IVVM). At 27 weeks of age animals were fasted overnight, and on the morning of the IVVM experiment animals were anaesthetized, instrumented, and mechanically ventilated. The extensor digitorum longus muscle was blunt dissected, isolated, and reflected over a glass coverslip or a gas exchange chamber (GEC) fitted in the stage of an inverted microscope. Microvascular hemodynamic responses were recorded during baseline and hyperinsulinemic-euglycemic clamp without perturbation (Protocol 1) and during sequential changes in GEC [O Results: In protocol 1, SD rats had a significant increase in red blood cell (RBC) velocity, RBC supply rate (SR), and RBC oxygen saturation (SO Conclusion: SD rats had a robust increase in capillary hemodynamics during hyperinsulinemic-euglycemic clamp whereas the capillary hemodynamics in ZDSD rats did not significantly change. Additionally, SD and ZDSD rats lacked expected hemodynamic responses in response to local [O
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