ArticleRSC advances2025
Study on the properties and
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Decoding the interplay between protic ionic liquids and drug: spectrophotometric, electrochemical, and DFT exploration of mitoxantrone.RSC advances · 2026Article
- Integrating green chemistry with biomedical innovation: the role of biocompatible ionic liquids and ionic liquid nanoparticles in therapeutic applications.RSC advances · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combining ionic liquids with active pharmaceutical ingredients (API-ILs) is an ideal strategy to improve the biopharmaceutical properties of APIs while preserving their efficacy. The appropriate selection of anions and cations for the formation of ILs eliminates the problems of solid drugs and retains the core ideal characteristics of the ionic liquid material state. In this study, API-ILs were prepared using matrine (Mat) as a cation and non-steroidal anti-inflammatory drugs (NSAIDs) as anions to improve the undesirable properties of NSAIDs and prepare API-ILs with dual functions. Mass spectrometry showed that the drug molecules exist as anions and cations in the ionic liquid. Infrared, nuclear magnetic and computer simulations demonstrated that Mat-NSAID interactions were mediated by hydrogen bonds, ionic bonds and van der Waals forces. Evaluation of physicochemical properties shows that ILs exhibited better solubility, where the solubilities of loxoprofen and diclofenac were 287 and 220 times higher, respectively, than that of the bulk drug. In addition, cytotoxicity tests were performed prior to
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.