Evidence map›Paper›PMID 40337171›Full record

SynthesisFrontiers in neurology2025

The application of diffusion tensor imaging in patients with mild cognitive impairment: a systematic review and meta-analysis.

Xinle Zhao, Mengyue You, Wenyu Ren, Lixin Ji, Yongbo Liu, Meng Lu

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinle ZhaoHenan University of Chinese Medicine, Zhengzhou, China.
Mengyue YouHenan University of Chinese Medicine, Zhengzhou, China.
Wenyu RenHenan University of Chinese Medicine, Zhengzhou, China.
Lixin JiLuoyang Branch of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Luoyang Hospital of TCM, Luoyang, China.
Yongbo LiuLuoyang Branch of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Luoyang Hospital of TCM, Luoyang, China.
Meng LuHenan University of Chinese Medicine, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To systematically evaluate the diagnostic value of diffusion tensor imaging (DTI) for mild cognitive impairment (MCI) based on Meta-analysis. Materials and methods: Databases including PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and VIP database were searched for literature on the use of DTI in studying MCI. The search was conducted from the inception of each database up to February 20, 2024. Literature was screened based on predefined inclusion and exclusion criteria, relevant data were extracted, and the quality of the included studies was assessed using the QUADAS-2 tool. Heterogeneity was evaluated using the Q-test and Results: A total of 76 studies were included (41 in English and 35 in Chinese). The overall pooled WMD and its 95% CI were -0.03 [-0.04, -0.03], with statistically significant differences in all brain regions except for the occipital lobe and the posterior limb of the internal capsule. Conclusion: DTI technology can identify microstructural damage in the brain white matter of MCI patients, which holds significant implications for early diagnosis and intervention.

Indexed as

Alzheimer’s diseasediffusion tensor imagingeldermild cognitive impairmentwhite matter

Identifiers

PMID40337171
PMCPMC12056378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.