Evidence map›Paper›PMID 40337055›Full record

ArticleIndian journal of surgical oncology2025

Clinical Progression on Neoadjuvant Chemotherapy: An Indicator of Poor Outcomes in Extremity Osteosarcoma.

Chandra Kumar Krishnan, Madhusudan Reddy Karagiri, Venkatraman Radhakrishnan, Anand Raja

Abstract read
In one paragraph

Article in Indian journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chandra Kumar KrishnanDepartment of Surgical Oncology, Cancer Institute (WIA), No: 38, Sardar Patel Road, Adyar, Chennai, 600036 India.
Madhusudan Reddy KaragiriDepartment of Surgical Oncology, Continental Hospitals, Hyderabad, India.
Venkatraman RadhakrishnanDepartment of Medical Oncology and Pediatric Oncology, Cancer Institute (WIA), No: 38, Sardar Patel Road, Adyar, Chennai 600036 India.
Anand RajaDepartment of Surgical Oncology, Cancer Institute (WIA), No: 38, Sardar Patel Road, Adyar, Chennai, 600036 India.ORCID 0000-0002-2585-8527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteosarcoma is a matrix-producing neoplasm. Most patients are treated with neoadjuvant chemotherapy (NACT. Various parameters are available for response assessment which include radiological and histological criteria. Data on clinical responses such as pain response and size assessment is meagre. In this study, we aimed to analyze if clinical assessment used for response evaluation can predict prognosis in patients receiving neoadjuvant chemotherapy for extremity osteosarcoma. All patients diagnosed with osteosarcoma and who underwent treatment with curative intent between January 2000 and December 2018 were identified. Patients who had progression were identified and whether clinical progression impacted overall survival (OS) and disease-free survival (DFS) was analyzed. Forty-three patients who had progression on NACT were identified. When compared to patients who did not have clinical progression, more patients in the clinical progression group had large tumors (

Indexed as

Neoadjuvant therapyOsteosarcomaPrognosisSurvival rate

Identifiers

PMID40337055
PMCPMC12052648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.