Evidence map›Paper›PMID 40337000›Full record

ArticleChemical science2025

A mechanistic continuum of nucleophilic aromatic substitution reactions with azole nucleophiles.

Harrison W Toll, Xiaoyi Zhang, Tong Gao, Guilherme Dal Poggetto, Mikhail Reibarkh, Joshua J Lee, Katherine J Yang, Eugene E Kwan, Amanda K Turek

Abstract read
In one paragraph

Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harrison W TollDepartment of Chemistry, Williams College 47 Lab Campus Drive Williamstown Massachusetts 01267 USA akt2@williams.edu.ORCID https://orcid.org/0000-0002-3653-2426
Xiaoyi ZhangDepartment of Chemistry, Williams College 47 Lab Campus Drive Williamstown Massachusetts 01267 USA akt2@williams.edu.ORCID https://orcid.org/0009-0000-4278-7743
Tong GaoDepartment of Chemistry, Williams College 47 Lab Campus Drive Williamstown Massachusetts 01267 USA akt2@williams.edu.ORCID https://orcid.org/0009-0002-4246-6012
Guilherme Dal PoggettoAnalytical Research and Development, MRL, Merck & Co., Inc. Rahway New Jersey 07065 USA.ORCID https://orcid.org/0000-0003-0591-9166
Mikhail ReibarkhAnalytical Research and Development, MRL, Merck & Co., Inc. Rahway New Jersey 07065 USA.
Joshua J LeeDepartment of Chemistry, Williams College 47 Lab Campus Drive Williamstown Massachusetts 01267 USA akt2@williams.edu.
Katherine J YangDepartment of Chemistry, Williams College 47 Lab Campus Drive Williamstown Massachusetts 01267 USA akt2@williams.edu.
Eugene E KwanMerck & Co., Inc. 33 Avenue Louis Pasteur Boston Massachusetts 02115 USA.ORCID https://orcid.org/0000-0001-7037-0531
Amanda K TurekDepartment of Chemistry, Williams College 47 Lab Campus Drive Williamstown Massachusetts 01267 USA akt2@williams.edu.ORCID https://orcid.org/0000-0001-5610-9169

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleophilic aromatic substitution (S

Identifiers

PMID40337000
PMCPMC12053731

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.