Evidence map›Paper›PMID 40336950›Full record

ArticleFrontiers in immunology2025

Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against

Ti Lu, Skyler T Kramer, Mary A York, Mst Nusrat Zahan, Debaki R Howlader, Zackary K Dietz, Sean K Whittier, Nathan J Bivens, Alexander Jurkevich, Lyndon M Coghill and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ti LuBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Skyler T KramerBioinformatics and Analytic Core, University of Missouri, Columbia, MO, United States.
Mary A YorkBioinformatics and Analytic Core, University of Missouri, Columbia, MO, United States.
Mst Nusrat ZahanBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Debaki R HowladerBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Zackary K DietzBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Sean K WhittierBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Nathan J BivensGenomics Technology Core, University of Missouri, Columbia, MO, United States.
Alexander JurkevichAdvanced Light Microscopy Core, University of Missouri, Columbia, MO, United States.
Lyndon M CoghillBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
William D PickingBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.
Wendy L PickingBond Life Sciences Center and Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, United States.

Funding

Vaccines to counter emerging antibiotic resistance (R01AI138970)R01AI138970 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PICKING, WENDY L. · 2018 to 2022
$6.0M
NIAID NIH HHS R01 AI138970
6 · The paper itself

Abstract

Shigellosis remains a global public health problem, especially in regions with poor sanitation measures. Our prior work has demonstrated the protective efficacy of a three-dose regimen of L-DBF, a recombinant fusion of IpaD and IpaB from

Indexed as

Dysentery, BacillaryShigella flexneriShigella VaccinesAnimalsAntigens, BacterialBacterial ProteinsFemaleHumansLungMiceMyocytes, CardiacAntigens, BacterialBacterial ProteinsShigella Vaccinescardiomyocytesfibroblastsimmune modulationintranasal vaccineShigellaspatial transcriptomics

Identifiers

PMID40336950
PMCPMC12056741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.