Efficacy of nitric oxide donors and EDTA against

Aaron Crowther, Gareth LuTheryn, Ramón Garcia-Maset, Maryam Parhizkar, J Mark Sutton, Charlotte Hind, Dario Carugo

Abstract read

In one paragraph

Article in Biofilm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.Bioactive materials · 2027
Review
EDTA enhances antimicrobial activity of PR-39 and Protegrin-1 antimicrobial peptides against carbapenem-resistant Pseudomonas aeruginosa in serum.Folia microbiologica · 2026
Article
Low concentrations of tetrasodium EDTA cause significant killing of biofilm-associated Pseudomonas aeruginosa in high-validity models of chronic wound and cystic fibrosis lung infections - but not in a model of endotracheal tube colonization.Access microbiology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaron CrowtherDepartment of Pharmaceutics, School of Pharmacy, University College London, London, UK.

Gareth LuTherynNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Ramón Garcia-MasetCentre for Urological Biology, Division of Medicine, University College London, London, UK.

Maryam ParhizkarDepartment of Pharmaceutics, School of Pharmacy, University College London, London, UK.

J Mark SuttonUK Health Security Agency, Vaccine Development and Evaluation Centre, Porton Down, Salisbury, UK.

Charlotte HindUK Health Security Agency, Vaccine Development and Evaluation Centre, Porton Down, Salisbury, UK.

Dario CarugoDepartment of Pharmaceutics, School of Pharmacy, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opportunistic pathogen

Indexed as

BiofilmChronic woundCiprofloxacinEDTANitric oxideNONOatePseudomonas aeruginosa

Identifiers

PMID40336941

DOI10.1016/j.bioflm.2025.100280

PMCPMC12056783

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.