Evidence map›Paper›PMID 40336824›Full record

ArticleNpj gut and liver2025

Steatotic liver disease is a marker of multimorbidity, not underlying cirrhosis, in older adults.

O Oduwole, C Ding, N Bitar, D Nair, S Salter, M Silverman, R Allen, L Ng Fat, E Tsochatzis, S Bell and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj gut and liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

O Oduwole *Institute for Liver and Digestive Health, University College London, London, UK.
C Ding *Institute for Liver and Digestive Health, University College London, London, UK.
N BitarInstitute for Liver and Digestive Health, University College London, London, UK.
D NairDepartment of Clinical Biochemistry, Royal Free Hospital, London, UK.
S SalterDepartment of Clinical Biochemistry, Royal Free Hospital, London, UK.
M SilvermanPatient and public involvement and engagement (PPIE) representative, London, UK.
R AllenPatient and public involvement and engagement (PPIE) representative, London, UK.
L Ng FatResearch Department of Epidemiology and Public Health, University College London, London, UK.
E TsochatzisInstitute for Liver and Digestive Health, University College London, London, UK.
S BellPrecision Breast Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK.
G MehtaInstitute for Liver and Digestive Health, University College London, London, UK.
A BrittonResearch Department of Epidemiology and Public Health, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steatotic liver disease (SLD) prevalence in adults is estimated at 30%, but older populations are understudied. Here, SLD prevalence and associated risk factors were assessed 1,021 Whitehall II study participants (mean age 72.5) using transient elastography (FibroScan). SLD was present in 33.3% (CAP ≥ 275 dB/m), with most classified as metabolic dysfunction-associated SLD. Only 2.4% had significant fibrosis ( ≥ 7.9 kPa). Adjusted for age and sex, SLD was associated with low physical activity (OR 1.60, 95% CI 1.13-2.27), poorer motor function (SF-36 PCS OR 1.21, 95% CI 1.05-1.40), difficulties in activities of daily living (OR 3.19, 95% CI 1.17-8.64), and multimorbidity (OR 1.45, 95% CI 1.22-1.73). These associations persisted after adjustment for socioeconomic, behavioural, and cardiometabolic risk factors. Frailty was associated with SLD at higher CAP thresholds ( ≥ 290 dB/m). In this older adult sample, SLD is common and appears more as a marker of multimorbidity and low physical activity than significant fibrosis.

Indexed as

Non-alcoholic fatty liver diseaseNon-alcoholic steatohepatitis

Identifiers

PMID40336824
PMCPMC12052588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.