Evidence map›Paper›PMID 40336815›Full record

ArticleFrontiers in veterinary science2025

Haspin kinase inhibition dampens pseudorabies virus infection

Lei Tan, Yong Yang, Xiaojiu Huang, Youqing Yuan, Kaixin Wang, Xiaoye Peng, Yiyan He, Yijin Wang, Lei Lei, Yingyi Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Virus infection and vesicle trafficking.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lei TanCollege of Animal Science and Technology, Yangtze University, Jingzhou, China.
Yong YangYunnan Sino-Science Gene Technology Co., Ltd., Kunming, China.
Xiaojiu HuangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Youqing YuanDepartment of Chemistry, University College London, London, United Kingdom.
Kaixin WangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Xiaoye PengCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Yiyan HeCollege of Animal Science and Technology, Yangtze University, Jingzhou, China.
Yijin WangCollege of Animal Science and Technology, Yangtze University, Jingzhou, China.
Lei LeiCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Yingyi ChenCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Deyong DuanCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Naidong WangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Yi YangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Feiyan DaiCollege of Veterinary Medicine, Yunnan Agricultural University, Kunming, China.
Cuiqing HuangFujian Provincial Key Laboratory for Prevention and Control of Animal Infectious Diseases and Biotechnology, Longyan University, Longyan, China.
Aibing WangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudorabies virus (PRV) represents a considerable infectious threat to the swine industry in China and poses potential health risks to humans. However, there is a notable lack of specific antiviral agents aimed at combating PRV. Haspin is involved in histone phosphorylation during mitosis, while the role of swine Haspin in PRV infection has not been previously investigated. In the present study, we demonstrated that Haspin expression was significantly enhanced in response to PRV infection. Overexpression of the

Indexed as

antiviral activityCHR-6494Haspin kinasepseudorabies virusreplication stage

Identifiers

PMID40336815
PMCPMC12055825

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.