Evidence map›Paper›PMID 40336333›Full record

ArticleJournal of evolutionary biology2025

The Tree of Sex consortium: a global initiative for studying the evolution of reproduction in eukaryotes.

Daniel Jeffries, Chiara Benvenuto, Astrid Böhne, Christelle Fraïsse, Sònia Garcia, Paul Jay, Lukáš Kratochvíl, Caitlin E McDonough-Goldstein, Aurora Ruiz-Herrera, Cibele G Sotero-Caio and 4 more

Abstract read
In one paragraph

Article in Journal of evolutionary biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Chromosome-specific drift under stabilizing selection generates polygenic barriers to sex chromosome turnover.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel JeffriesDivision of Evolutionary Ecology, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland.ORCID 0000-0003-1701-3978
Chiara BenvenutoEnvironmental Research and Innovation Centre (ERIC), School of Science, Engineering and Environment, University of Salford, Salford, United Kingdom.ORCID 0000-0002-8378-8168
Astrid BöhneCentre for Molecular Biodiversity Research, Leibniz Institute for the Analysis of Biodiversity Change LIB, Museum Koenig Bonn, Bonn, Germany.ORCID 0000-0002-1284-3115
Christelle FraïsseCNRS, Univ. Lille, UMR 8198 - Evo-Eco-Paleo, Lille, France.ORCID 0000-0001-8441-5075
Sònia GarciaInstitut Botànic de Barcelona, IBB (CSIC-CMCNB), Barcelona, Spain.ORCID 0000-0002-3143-0527
Paul JayCenter for GeoGenetics, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5979-1263
Lukáš KratochvílDepartment of Ecology, Faculty of Science, Charles University, Prague, Czech Republic.ORCID 0000-0002-3515-729X
Caitlin E McDonough-GoldsteinDepartment of Integrative Biology, University of Wisconsin-Madison, Wisconsin, United States of America.ORCID 0000-0001-8949-7479
Aurora Ruiz-HerreraDepartament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.ORCID 0000-0003-3868-6151
Cibele G Sotero-CaioTree of Life, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.ORCID 0000-0002-3112-0000
Nicole ValenzuelaDepartment of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA, United States.ORCID 0000-0003-1148-631X
Melissa A WilsonSchool of Life Sciences, Arizona State University, Tempe, AZ, United States.ORCID 0000-0002-2614-0285
Tree of Sex Consortium
Kamil S JaronTree of Life, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.ORCID 0000-0003-1470-5450

Funding

Population dynamics and medical consequences of sex chromosome evolutionR35GM124827 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI WILSON, MELISSA A · 2017 to 2024
$2.7M
Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR 2021SGR00122Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR 2021SGR00315Agència de Gestió d'Ajuts Universitaris i de Recerca, AGAUR IOS 2127995Association for the Study of Animal BehaviourCatalan Institution for Research and Advanced StudiesCzech Science Foundation 23-07665SDeutsche Forschungsgemeinschaft 492407022Deutsche Forschungsgemeinschaft 497674620 / 1Human Frontier Science Program LT0033/2022-LNational Science Foundation DBI 2208973NIGMSNIGMS NIH HHS R35 GM124827NIH HHS R35GM124827Spanish Ministry of Science and Innovation AEI/10.13039/501100011033Spanish Ministry of Science and Innovation PID2020-112557GB-I00Swiss National Science Foundation TMAG-3_209309Wellcome TrustWellcome Trust 220540
6 · The paper itself

Abstract

Reproduction is a fundamental aspect of life that affects all levels of biology, from genomes and development to population dynamics and diversification. The first Tree of Sex database synthesized a vast diversity of reproductive strategies and their intriguing distribution throughout eukaryotes. A decade on, we are reviving this initiative and greatly expanding its scope to provide the most comprehensive integration of knowledge on eukaryotic reproduction to date. In this perspective, we first identify important gaps in our current knowledge of reproductive strategies across eukaryotes. We then highlight a selection of questions that will benefit most from this new Tree of Sex project, including those related to the evolution of sex, modes of sex determination, sex chromosomes, and the consequences of various reproductive strategies. Finally, we outline our vision for the new Tree of Sex database and the consortium that will create it (treeofsex.org). The new database will cover all Eukaryota and include a wide selection of biological traits. It will also incorporate genomic data types that were scarce or non-existent at the time of the first Tree of Sex initiative. The new database will be publicly accessible, stable, and self-sustaining, thus greatly improving the accessibility of reproductive knowledge to researchers across disciplines for years to come. Lastly, the consortium will persist after the database is created to serve as a collaborative framework for research, prioritizing ethical standards in the collection, use, and sharing of reproductive data. The new Tree of Sex consortium is open, and we encourage all who are interested in this topic to join us.

Indexed as

Biological EvolutionEukaryotaReproductionSex Determination Processesasexual reproductionbiodiversitydatabaseontologysex chromosomessex determinationsexual reproduction

Identifiers

PMID40336333
PMCPMC12317844

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.