Evidence map›Paper›PMID 40336217›Full record

ArticleChirality2025

Quantification of Oseltamivir Phosphate Enantiomeric Impurity by Chiral HPLC Method With the Aid of Solvent Extraction and Phosphate Salt-Out Method.

Torati Srinivas, K V N Suresh Reddy, Challa Madhavi, M Kiranmai Reddy

Abstract read
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Article in Chirality, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Torati SrinivasDepartment of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Visakhapatnam, AP, India.
K V N Suresh ReddyDepartment of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Visakhapatnam, AP, India.ORCID https://orcid.org/0000-0001-8673-474X
Challa MadhaviDepartment of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Visakhapatnam, AP, India.
M Kiranmai ReddyDepartment of Life Sciences, GITAM School of Science, GITAM (Deemed to be University), Visakhapatnam, AP, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A robust chiral high-performance liquid chromatography (HPLC) method was established to separate and quantify the enantiomeric impurity (3S, 4S, 5R) in oseltamivir phosphate. A new sample preparation approach was used, involving the solvent extraction method to remove phosphate salt from the drug, thereby preventing the column's clogging and confirming method repeatability. Thin-layer chromatography (TLC) was employed to identify oseltamivir in the organic layer, while

Indexed as

Drug ContaminationOseltamivirPhosphatesSolventsChromatography, High Pressure LiquidMagnetic Resonance SpectroscopySaltsStereoisomerismOseltamivirPhosphatesSaltsSolventsenantiomeric impurity (3S, 4S, 5R)oseltamivir phosphatesalt‐out processsolvent extraction

Identifiers

PMID40336217
PMCPMC12058278

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.