Evidence map›Paper›PMID 40336139›Full record

ArticleBMC sports science, medicine & rehabilitation2025

Association between muscle strength gains and biventricular cardiac remodeling in response to high-intensity resistance training in healthy untrained males: a longitudinal study.

Nicolas Pamart, Joffrey Drigny, Hélène Azambourg, Marion Remilly, Kamal Lahjaily, Amélia Rocamora, Francois Tournoux, Eric Saloux, Emmanuel Reboursière, Antoine Gauthier and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04187170 (Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04187170 nacompletednot on this map

Longitudinal Analysis of Right Ventricular Remodeling in Response to Prolonged Strength Training Using 3D-echocardiography

TypeinterventionalSponsorUniversity Hospital, CaenRan2022 to 2023Enrolled27ConditionsCardiac Remodeling, Ventricular, Right Ventricular HypertrophyArmsStrength physical training
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicolas PamartInter-University Laboratory of Human Movement Science (LIBM EA7424), University of Lyon, University Jean Monnet, Saint-Etienne, France.
Joffrey DrignyDepartment of Sports Medicine, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France.
Hélène AzambourgDepartment of Sports Medicine, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France.
Marion RemillyDepartment of Sports Medicine, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France.
Kamal LahjailyDepartment of Cardiology, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France.
Amélia RocamoraCentre de Recherche Clinique (CRC), CHU Caen Normandie, Caen, 14000, France.
Francois TournouxResearch Center of the Montreal University Hospital (CRCHUM), Montreal, QC, Canada.
Eric SalouxDepartment of Cardiology, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France.
Emmanuel ReboursièreDepartment of Sports Medicine, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France.
Antoine GauthierNormandie Univ, UNICAEN, UFR STAPS, Caen, 14000, France.
Amir HodzicDepartment of Sports Medicine, Normandie Univ, UNICAEN, CHU Caen Normandie, Caen, 14000, France. hodzic-a@chu-caen.fr.

Funding

Société Francaise de Cardiologie Bourse Sport et Coeur
6 · The paper itself

Abstract

backgroundHigh-intensity resistance training induces structural and functional adaptations in skeletal muscle, yet its impact on cardiac remodeling remains debated. This study aimed to investigate the longitudinal biventricular cardiac response to a 20-week high-intensity resistance training program in previously untrained, healthy males and examine the association between muscle strength gains and cardiac remodeling.

methodsTwenty-seven male volunteers (aged 18-40 years) participated in a high-intensity resistance training program for 20 weeks. Assessments at baseline, 12 weeks, and 20 weeks included resting blood pressure, electrocardiogram (ECG), three-dimensional transthoracic echocardiography (3DTTE), cardiopulmonary exercise testing ([Formula: see text]O

resultsTwenty-two participants completed the study. Resistance training led to significant reductions in arterial systolic and diastolic blood pressure and heart rate. After 20 weeks of training, 3DTTE showed a significant increase in left ventricular (LV) mass (120.1 ± 15.4 g vs. 133.7 ± 16.3 g, p < 0.001), without inducing LV hypertrophy. Balanced increases were observed in LV end-diastolic volume (146.4 ± 18.9 ml vs. 157.9 ± 19.6 ml, p < 0.001) and right ventricular (RV) end-diastolic volume (119 ± 19.4 ml vs. 129.2 ± 21.6 ml, p < 0.001). LV and RV systolic and diastolic function remained unchanged. There were no changes in [Formula: see text]O

conclusionThe resistance training program resulted in significant and rapid muscle strength gains and reduced blood pressure. Cardiac adaptations, including moderate biventricular dilatation, were observed without changes in cardiac function or [Formula: see text]O

trial registrationClinicalTrials.gov ID: NCT04187170.

Indexed as

3D echocardiographyAthlete’s heartBiventricular cardiac remodelingCardiac hypertrophyMuscle strengthResistance training

Identifiers

PMID40336139
PMCPMC12057098

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.