ArticleJournal of pharmaceutical health care and sciences2025
Nonsteroidal anti-inflammatory drug use is associated with improved activities of daily living and rehabilitation in older adult patients following a fracture: a retrospective cohort study.
Article in Journal of pharmaceutical health care and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correction: Nonsteroidal anti-inflammatory drug use is associated with improved activities of daily living and rehabilitation in older adult patients following a fracture: a retrospective cohort study.Journal of pharmaceutical health care and sciences · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsufficient rehabilitation due to postfracture pain can result in muscle atrophy and joint contractures, which may affect the improvement of activities of daily living (ADL). This study investigated the impact of using nonsteroidal anti-inflammatory drugs (NSAIDs) on the improvement of ADL in older adult patients with fractures admitted to a convalescent rehabilitation unit.
methodsOf 489 older adult patients with fractures from January 2017 to June 2019, 261 fulfilled the requirements for this retrospective cohort analysis. Patients who had convalescent rehabilitation following a fracture were categorized into two groups: those who used NSAIDs and those who did not. The functional independence measure-total gain (FIM-total) score, which was used for evaluating ADL, was the main outcome measure. We ascertained the independent relationship between NSAIDs use and rehabilitation outcomes using a multiple linear regression analysis. Covariates selected to correct bias included age, sex (male), BMI, hypertension, dementia, cardiovascular disease, cerebrovascular disease, upper limb paralysis, femoral fracture, lumbar compression fracture, thoracic compression fracture, pelvic fracture, patellar fracture, FIM-total at admission, number of drugs, acetaminophen use.
resultsThe mean participant age was 82.3 ± 7.4 years, 69 (26.4%) of them were men, and 94 (36%) used NSAIDs. Multiple linear regression analysis revealed that NSAIDs use was independently associated with FIM-total gain during hospitalization (β=2.311, P=0.013).
conclusionsThese findings suggest that the appropriate use of NSAIDs may play a beneficial role in maximizing rehabilitation outcomes. However, careful monitoring for potential adverse effects is essential, particularly in older adults.
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