Evidence map›Paper›PMID 40336049›Full record

ArticleThrombosis journal2025

Endoplasmic reticulum protein 29 negatively regulates platelet functions and thrombosis in mice.

Xiaofeng Yan, Yishan Lu, Keyu Lv, Miao Jiang, Chao Fang, Yi Wu, Aizhen Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaofeng YanCollaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Cyrus Tang Medical Institute, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, China.
Yishan LuCollaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Cyrus Tang Medical Institute, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, China.
Keyu LvDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Miao JiangCollaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Cyrus Tang Medical Institute, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, China.
Chao FangDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. fangc@hust.edu.cn.
Yi WuCollaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Cyrus Tang Medical Institute, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, China. wuy@suda.edu.cn.
Aizhen YangCollaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Cyrus Tang Medical Institute, The Fourth Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, China. yangaizhen@suda.edu.cn.

Funding

the collaboration fund from State Key Laboratory of Radiation Medicine and Protection GZN1201802the Jiangsu Provincial Medical Innovation Center CXZX202201the National Natural Science Foundation of China 31970890, 82270136, 82200147the National Natural Science Foundation of China 82170129, 81970128, 82470132, 81770138the Priority Academic Program Development of Jiangsu Higher Education Institutions PAPDthe Translational Research Grant of NCRCH 2020WSA04the Translational Research Grant of NCRCH 2020ZKPA02
6 · The paper itself

Abstract

backgroundSeveral members of protein disulfide isomerase (PDI) family with the CXYC active motif such as PDI, ERp57, ERp72, ERp46, ERp5 and TMX1 have important roles in platelet functions and thrombosis. These members contribute to the network of redox regulation of platelet activities. However, whether other PDI family members without the CXYC motif such as ERp29, have a role in these processes remains unknown.

aimsTo determine the role of ERp29 in platelet functions and thrombosis.

methodsThe phenotypes of platelet-specific ERp29-deficient (Pf4-Cre/ERp29

resultsCompared with WT mice, Pf4-Cre/ERp29 CONCLUSION(S): ERp29 is the first disulfide isomerase without the CXYC motif that negatively regulates platelet function. This study provides new insight into the redox network controlling thrombosis.

Indexed as

ERp29Integrin αIIbβ3PlateletsRedox regulationThrombosis

Identifiers

PMID40336049
PMCPMC12057190

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.