Evidence map›Paper›PMID 40336033›Full record

Trial reportBMC medicine2025

Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial.

Shi Zhang, Yi Wang, Xincheng Wang, Mingxin Leng, Renjiao Liu, Zhouhuiling Li, Jing Li, Jixuan Xiao, Dangmin Hou, Xinying Gao and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shi Zhang *Department of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Yi Wang *Department of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Xincheng WangDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Mingxin LengDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Renjiao LiuDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Zhouhuiling LiDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Jing LiDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Jixuan XiaoDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Dangmin HouDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Xinying GaoDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.
Chunjun LiDepartment of Health Management Center, Endocrinology, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China. li_chunjun@126.com.

Funding

Tianjin Health Research Project TJWJ2022MS019Tianjin Union Medical Center 2021YJ002
6 · The paper itself

Abstract

backgroundThis study aimed to explore the effects of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on weight loss and diabetes remission in adults with obesity and newly diagnosed prediabetes/type 2 diabetes (T2D).

methodsParticipants with obesity and newly diagnosed prediabetes or T2D (n = 61) were randomly allocated to standard treatment group (conventional medication and lifestyle guidance for 12 months) and intensive treatment group (in addition to conventional medication, a high protein diet and moderate exercise were given for 12 months).

resultsBy month 12, 60 (98.4%) participants completed the 12-month follow-up visit. In the intensive treatment group, 73.33% patients in the prediabetes subgroup returned to normoglycemia and the diabetes remission rate was 86.67% in the diabetes subgroup, which were much higher than the remission rate of prediabetes subgroup (7.69%) and diabetes subgroup (16.67%) in the standard treatment group (P < 0.001). The mean weight change was - 19.29 kg (95% CI, - 22.95 to - 15.63) in the intensive treatment group and - 1.52 kg (95% CI, - 5.12 to 2.07) in the standard treatment group from baseline after intervention. The weight change between the two groups was significantly different (net difference, - 17.77 kg; 95% CI, - 22.90 to - 12.64; P < 0.001). Percent of body fat, visceral fat area, and hepatic controlled attenuation parameter value reduced significantly in the intensive treatment group compared to the standard treatment group (P < 0.001).

conclusionsHypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise could lead to a considerable proportion of patients with diabetes achieving diabetes remission.

trial registrationchictr.org.cn ChiCTR2100044305.

Indexed as

Diabetes Mellitus, Type 2Diet, High-ProteinExerciseExercise TherapyHypoglycemic AgentsObesityWeight LossAdultAgedFemaleHumansMaleMiddle AgedPrediabetic StateRemission InductionTreatment OutcomeHypoglycemic AgentsHigh protein dietHypoglycemic agentsModerate exerciseObesityRemissionType 2 diabetesWeight loss effect

Identifiers

PMID40336033
PMCPMC12060396

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.