ArticleBMC nephrology2025
Inflammatory and nutritional indices for overall survival in Hemodialysis patients: a multicenter cohort study.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Combined Assessment of Serum dp-ucMGP and Albumin in Relation to All-Cause and Cardiovascular Mortality in Hemodialysis Patients.International journal of molecular sciences · 2026Observational
- Association of Neutrophil-to-Lymphocyte Ratio and C-Reactive Protein-to-Albumin Ratio with Renal Anemia in Maintenance Hemodialysis Patients.Pakistan journal of medical sciences · 2026Article
- Development and validation of a sepsis-specific systemic inflammation classification system for mortality prediction.Frontiers in medicine · 2026Article
- Data-driven cluster analysis identifies three clinical phenotypes in hemodialysis patients.Renal failure · 2025Article
- Prediction of Mortality in Hemodialysis Patients Using Inflammation- and Nutrition-Based Indices.Journal of personalized medicine · 2025Article
- Association between inflammatory markers and mortality in hemodialysis patients.Jornal brasileiro de nefrologiaArticle
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Authors and funding
6 authors.
Funding
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Abstract
objectiveThis study aimed to re-evaluate the prognostic value of inflammation and nutrition-related indices in a large multicenter cohort of hemodialysis patients from 138 dialysis centers in Beijing.
methodsThis retrospective cohort study included 6,679 hemodialysis patients. Indices were calculated from routine laboratory parameters. Survival analyses included Kaplan-Meier curves and multivariate Cox models. C-index, receiver operating characteristic curves and decision curve analysis were used to evaluate the predictive ability of the different indicators.
resultsAll indicators (including Prognostic Nutritional Index [PNI], Lymphocyte-to-CRP Ratio [LCR], CRP-to-Albumin Ratio [CAR], Systemic Immune-Inflammation Index [SII], Platelet-to-Lymphocyte Ratio [PLR], and Neutrophil-to-Lymphocyte Ratio [NLR]) except for PLR were identified as independent predictors of OS (overall survival). Among these indicators, the PNI consistently demonstrated superior discriminatory ability in predicting outcomes among hemodialysis patients. Multivariate Cox regression analysis showed that the risk of mortality in hemodialysis decreased with an increase in PNI (adjusted HR 0.78, 95% CI: 0.75-0.82, P < 0.01). The optimal cut-off value for PNI was determined to be 42.3.
conclusionsPNI has demonstrated better reliability as a prognostic indicator for hemodialysis patients compared with LCR, CAR, SII, PLR and NLR. The efficient assessment of PNI effectively identifies high-risk individuals and highlights its significance as a valuable prognostic tool in clinical settings.
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