ArticleMolecular diversity2025
Unraveling potent Glycyrrhiza glabra flavonoids as AKT1 inhibitors using network pharmacology and machine learning-assisted QSAR.
Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Deciphering the molecular mechanism of sesamol in inflammatory bowel disease through an integrative computational and biological evaluation of the JAK1 signalling pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Plants, Pills, and the Brain: Exploring Phytochemicals and Neurological Medicines.International journal of plant, animal and environmental sciences · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycyrrhiza glabra (G. glabra) phytocompounds have been reported to interact with neurological targets, including those implicated in epilepsy, and may modulate epilepsy-related targets. While substantial evidence supports their potential antiepileptic effects, the underlying molecular mechanisms remain unclear. This study aims to elucidate the molecular mechanism of G. glabra phytocompounds by integrating network pharmacology and machine learning (ML)-based quantitative structure-activity relationship (QSAR) techniques. Network pharmacology analysis identified AKT1 as a key epilepsy-related target, and four ML-based 2D-QSAR models were developed using AKT1 inhibitors. The developed models underwent comprehensive validation, including internal and external validation, Y-randomization, statistical analysis, and applicability domain assessment to ensure robustness and reliability. Among them, the Multilayer Perceptron (MLP) model excelled as the most robust and demonstrated superior predictive ability with a correlation coefficient r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.