Evidence map›Paper›PMID 40335816›Full record

ArticleClinical and experimental nephrology2025

Clinicopathological findings of tubulointerstitial nephritis: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR).

Keiko Oda, Joichi Usui, Yukiko Kanetsuna, Tomohiro Murata, Takaya Ozeki, Akira Shimizu, Hitoshi Sugiyama, Shoichi Maruyama, Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology

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Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keiko OdaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. k-oda@med.mie-u.ac.jp.
Joichi UsuiDepartment of Nephrology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Yukiko KanetsunaDepartment of Clinical Pathology, International University of Health and Welfare Atami Hospital, Atami, Japan.
Tomohiro MurataDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Takaya OzekiDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Akira ShimizuDepartment of Analytic Human Pathology, Nippon Medical School, Tokyo, Japan.
Hitoshi SugiyamaDepartment of Human Resource Development of Dialysis Therapy for Kidney Disease, Dentistry and Pharmaceutical Sciences, Okayama University Institute of Academic and Research of Medicine, Okayama, Japan.
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTubulointerstitial nephritis (TIN) is an important disease involving a diverse set of factors that can cause both acute kidney injury and chronic kidney disease. The purpose of this cross-sectional study was to clarify the causative diseases and clinicopathological characteristics of TIN using the Japan Renal Biopsy Registry (J-RBR).

methodsThis cross-sectional study analyzed data from 22,049 cases registered in the J-RBR between 2018 and 2022. Clinicopathological findings at diagnosis were investigated.

resultsOf the enrolled cases, 913 were diagnosed with TIN. "Drug-induced" was the most common (232 cases, 25.7%), followed by "IgG4-related kidney disease" (124 cases, 13.7%). Of "Drug-induced" TIN cases, "Chemotherapy-related" was the most common cause (63 cases, 27.2%), including 47 cases of "immune checkpoint inhibitor (ICI)-associated" TIN. IgM-positive plasma cell-rich TIN (IgMPC-TIN), which has been the focus of much attention in recent years, was also included, with 9 cases.

conclusionThis is the first report of the clinicopathological findings of TIN patients in a large-scale, nationwide registry of renal biopsies. It was possible to identify recent trends in causative diseases, including an increase in chemotherapy-related TIN and IgMPC-TIN.

Indexed as

KidneyNephritis, InterstitialAdultAgedAged, 80 and overAntineoplastic AgentsBiopsyCross-Sectional StudiesFemaleHumansImmune Checkpoint InhibitorsJapanMaleMiddle AgedRegistriesYoung AdultAntineoplastic AgentsImmune Checkpoint InhibitorsClinicopathological featuresEtiologyIgM-positive plasma cell-rich TIN (IgMPC-TIN)Immune checkpoint inhibitor (ICI)-associated TINRenal biopsyTubulointerstitial nephritis (TIN)

Identifiers

PMID40335816

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