Evidence map›Paper›PMID 40335755›Full record

Observational studyInternational journal of colorectal disease2025

Prospective and multicenter study on clinical-biological factors predictive of chronic colon diverticulitis: DICRO Trial.

Marta Climent, Lucia Sobrino, Jordi Guardiola, Esther Kreisler, Sebastiano Biondo, DICRO Trial Group

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04407793 (Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04407793 unknown statusnot on this map

Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis

Typeobservational_patient_registrySponsorSebastiano BiondoRan2020 to 2023Enrolled500ConditionsAcute Diverticulitis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marta ClimentDepartment of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
Lucia SobrinoDepartment of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
Jordi GuardiolaDepartment of Gastronterology, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
Esther KreislerDepartment of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain.
Sebastiano BiondoDepartment of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, University of Barcelona, Barcelona, Spain. sbn.biondo@gmail.com.
DICRO Trial Group

Funding

Asociación Epañola de Cirujanos (AEC) 20PSJ019Fundacion Asociacion Española de Coloproctologia (FAECP) 20PSJ023
6 · The paper itself

Abstract

purposeThis manuscript presents the protocol for a prospective, multicenter study aimed at identifying prognostic factors for the recurrence of diverticulitis. The design, methodology, and analysis plan are detailed, providing a comprehensive framework for evaluating clinical endpoints and intervention outcomes in patients with diverticulitis.

methodsClinical, observational, prospective, and multicenter study of patients diagnosed with acute diverticulitis in the Emergency Department (ED) of 5 Spanish hospitals. The inclusion criteria were patients with acute diverticulitis who did not require emergency surgery. A 2-year follow-up will be carried out. The main objective is the description of prognostic factors of new episodes of acute diverticulitis and the creation of a therapeutic algorithm to select patients who could benefit from early elective surgery. Secondary endpoints are descriptive analyses of quality of life at different periods to establish the evolution of the disease and to correlate symptoms with systemic and local inflammatory markers; and sub-analysis of immunosuppressed patients to assess disease virulence.

conclusionDetermination of a marker predictive of recurrent disease or chronic inflammation would be of benefit in developing a good treatment strategy. One group that would particularly benefit is immunosuppressed patients.

trial registrationClinicalTrials.gov Identifier: NCT04407793.

Indexed as

Diverticulitis, ColonicBiomarkersChronic DiseaseFemaleHumansMalePrognosisProspective StudiesQuality of LifeRecurrenceBiomarkersAcute diverticulitisChronic diverticulitisDiverticulitis treatmentFecal calprotectinRecurrence

Identifiers

PMID40335755
PMCPMC12058879

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.