Trial reportClinical oral investigations2025
Zirconia-reinforced glass ionomer restorations in molar incisor hypomineralization: a randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05494749 (Effectiveness Of Zirconia Reinforced Glass Ionomer Used In Alternative Restorative Treatment In Molar Incisor Hypomineralization), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness Of Zirconia Reinforced Glass Ionomer Used In Alternative Restorative Treatment In Molar Incisor Hypomineralization (A Randomized Controlled Clinical Trial And Finite Element Analysis)
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non- and minimally invasive management of hypersensitivity in molar-incisor hypomineralisation (MIH) at home and in clinical practice: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Restorative interventions and management of primary and permanent molars affected by molar incisor hypo-mineralization: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Clinical performance of glass hybrid and short fiber-reinforced composite restorations in MIH-affected molars: A 60-month split-mouth randomized controlled trial.Clinical oral investigations · 2026Trial
- Bonding to Molar-Incisor Hypomineralization Affected Teeth: A Scoping Review of Adhesive Strategies, In Vitro Performance, and Clinical Outcomes.Frontiers in dentistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the effectiveness of zirconia-reinforced glass ionomer (ZrGI), in reducing pain and sensitivity, and to assess its clinical success in comparison to glass-hybrid glass ionomer (GhGI) in hypomineralized permanent first molars (HPFM) following the Atraumatic Restorative Treatment (ART) approach. MATERIALS AND
methodsThis randomized controlled clinical trial included 7-10-year-old children. Eighty-eight HPFMs with evidence of caries, with or without hypersensitivity were included. These molars scored (2a), (2b), (4a), or (4b) according to the MIH Treatment Need Index (MIH-TNI). Selective caries removal was performed using the ART protocol. The test group received ZrGI (Zirconomer®) restorations, and the control group received GhGI (Equia Forte®) restorations. Pain and sensitivity were assessed pre-operatively, using the Visual Analogue Scale (VAS), then re-assessed post-operatively after 1 week and after 3,6,9, and 12 months (M). Clinical success was evaluated, starting from the 3-month visit, using the ART evaluation criteria.
resultsAfter 12M, the median pain scores for the ZrGI gp., (Q1-Q3; 0.00 - 0.00) and GhGI gp., (Q1-Q3; 0.00 - 0.00) showed no statistically significant difference, (p = 0.329). Median sensitivity scores for the ZrGI gp., (Q1-Q3; 0.00 - 5.00) and the GhGI gp., (Q1-Q3;0.00 - 3.50), also showed no statistically significant difference, (p = 0.344). No significant difference was found between the 12M success rate of ZrGI (86.4%) and GhGI (84.1%), (p = 0.765).
conclusionRegarding the reduction of pain and sensitivity, and clinical success, zirconia-reinforced GIC was as effective as glass hybrid GIC in restoring HPFM, using the ART approach. CLINICAL SIGNIFICANCE: Zirconia-reinforced glass ionomer cement may be a promising restorative material due to its favorable physical properties and acceptable clinical results, as shown in this study. It may be used as an interim restoration in hypomineralized permanent first molars and holds potential for even wider applications in clinical pediatric dentistry.
trial registrationPlease refer to this study by its ClinicalTrials.gov identifier: NCT05494749.
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