ArticleNature2025
Oncogene aberrations drive medulloblastoma progression, not initiation.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
20 citing papers in PubMed.
- scAmp enables focal gene amplification analysis from single-cell data.Nature communications · 2026Article
- Paediatric therapeutic development workshop on medulloblastoma.British journal of cancer · 2026Review
- From developmental origins to relapse: molecular and therapeutic insights in medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Immune Cell Therapy Promises More Effective Cure for Medulloblastoma.Journal of personalized medicine · 2026Review
- Integrated Multi-Omics Analysis Reveals an HCMV-Associated Late-Gene Signature Associated with Poor Survival in Pediatric Group 3 Medulloblastoma.Biomedicines · 2026Article
- Modeling medulloblastoma pathogenesis and treatment in human cerebellar organoids.Genes & development · 2026Article
- Preservation and clonal behavior of extrachromosomal DNA in patient-derived xenograft models of childhood cancers.Genome medicine · 2026Article
- Computational origins of cortical brain circuits for social cognition.Nature reviews. Neuroscience · 2026Review
- Developmental determinants of male bias in medulloblastoma.bioRxiv : the preprint server for biology · 2026Article
- scAmp analyzes focal gene amplifications at single-cell resolution.bioRxiv : the preprint server for biology · 2026Article
- Cell-free DNA from cerebrospinal fluid cytology specimens as a novel liquid biopsy approach for pediatric patients with primary central nervous system tumors.Acta neuropathologica communications · 2026Article
- Strength through diversity: how cancers thrive when clones cooperate.Molecular oncology · 2026Review
- Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.Nature genetics · 2026Article
- Epigenetic regulation in medulloblastoma: from tumor heterogeneity to diagnostic, prognostic, and translational applications.Frontiers in molecular neuroscience · 2026Review
- Research on the Mechanism of "Cold Tumor" Formation and Immunotherapy for Its Transformation into "Hot Tumor".Oncology research · 2026Review
- Review
- Trends in central nervous system cancers mortality in the United States and the underlying sociodemographic determinants, 1999-2020.European journal of public health · 2025Article
- Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma.Nature communications · 2025Article
- Advancing Medulloblastoma Therapy in Pediatrics: Integrative Molecular Classification and Emerging Treatments.Brain sciences · 2025Review
- Comparison of spatial transcriptomics technologies using tumor cryosections.Genome biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Konstantin Okonechnikov *Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Piyush Joshi *Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-5631-336X
Verena Körber *Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anne RademacherDivision of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.ORCID 0000-0003-3054-3121
Michele BortolomeazziSingle-cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-5805-5774
Jan-Philipp MallmSingle-cell Open Lab, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-7059-4030
Jan VaillantHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0009-0003-6283-9581
Patricia Benites Goncalves da SilvaHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Britta StatzHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Mari SeppCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID 0000-0003-1733-8385
Ioannis SarropoulosCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.ORCID 0000-0002-2242-0562
Tetsuya YamadaCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany.
Andrea WittmannHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Kathrin SchrammHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Mirjam Blattner-JohnsonHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Petra FieselHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Barbara JonesHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Natalie JägerHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-9589-7580
Till MildeHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-7267-1052
Kristian W PajtlerHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-3562-6121
Cornelis M van TilburgHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0001-5274-910X
Olaf WittHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0003-3918-9157
Konrad BochennekFrankfurt University Hospital, Goethe University, Frankfurt, Germany.
Katharina Johanna WeberGoethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Frankfurt am Main, Germany.
Lisa NonnenmacherUniversity Children's Hospital, Ulm, Germany.
Christian ReimannUniversity Children's Hospital, Ulm, Germany.ORCID 0009-0005-2487-4313
David R GhasemiHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-3844-9933
Ulrich SchüllerDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-8731-1121
Martin MynarekDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-3302-2719
Stefan RutkowskiDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
David T W JonesHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-2036-5141
Andrey KorshunovHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Karsten RippeDivision of Chromatin Networks, German Cancer Research Center (DKFZ) and Bioquant, Heidelberg, Germany.ORCID 0000-0001-9951-9395
Frank WestermannHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0003-1584-3636
Supat ThongjueaHopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
Thomas HöferDivision of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Henrik KaessmannDivision of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7563-839X
Lena M KutscherHopp Children's Cancer Center (KiTZ), Heidelberg, Germany. l.kutscher@kitz-heidelberg.de.ORCID 0000-0002-1130-4582
Stefan M PfisterHopp Children's Cancer Center (KiTZ), Heidelberg, Germany. s.pfister@kitz-heidelberg.de.ORCID 0000-0002-5447-5322
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite recent advances in understanding disease biology, treatment of group 3/4 medulloblastoma remains a therapeutic challenge in paediatric neuro-oncology
Indexed as
CarcinogenesisCerebellar NeoplasmsChromosome AberrationsDisease ProgressionMedulloblastomaOncogenesCohort StudiesDNA Copy Number VariationsDrug Resistance, NeoplasmFemaleHumansMaleN-Myc Proto-Oncogene ProteinSingle-Cell AnalysisTranscriptomeMYCN protein, humanN-Myc Proto-Oncogene Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.