ArticleNature2025
Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Therapeutic potential and underlying mechanisms of engineered young plasma-derived exosomes in Alzheimer's disease.Bioactive materials · 2027Article
- Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Molecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability.Acta neuropathologica · 2026Article
- Pharmacological and Physiological Characteristics of Synaptic Transmissions From the Medial Prefrontal Cortex Onto Noradrenergic Neurons and Inhibitory Interneurons in the Mouse Locus Coeruleus.The European journal of neuroscience · 2026Article
- The locus coeruleus at the crossroads of inflammation and neurodegeneration in multiple sclerosis.Journal of neuroinflammation · 2026Review
- A projection atlas of excitatory and inhibitory inputs to the preBötzinger complex: substrates for multimodal breathing control.Journal of neurophysiology · 2026Article
- Mosaic: Single-Cell Atlas of Stress.Cells · 2026Review
- The monoaminergic systems as drivers of Alzheimer's disease pathophysiology and symptomatology.Current opinion in neurology · 2026Review
- Identification of a stress-sensitive endogenous opioid-containing neuronal population in the paranigral ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Decoding P300 as a shared neural mechanism for oddball target detection and working memory updating.iScience · 2026Article
- A Glutamatergic Medial Prefrontal Cortex-Locus Coeruleus Circuit Drives Intestinal Dysmotility in Diarrhea-Predominant Irritable Bowel Syndrome.International journal of molecular sciences · 2026Article
- Research progress on the role of the locus coeruleus in cognitive function.Frontiers in human neuroscience · 2026Review
- Noradrenergic tuning of arousal is coupled to movement transitions.Cell reports · 2025Article
- Top-down control of sustained attention by the medial prefrontal cortex (mPFC) - locus coeruleus (LC) circuit during the rodent continuous performance test (rCPT).bioRxiv : the preprint server for biology · 2025Article
- Napping restores working memory and brain activation impaired by sleep deprivation.IBRO neuroscience reports · 2025Article
- Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus.bioRxiv : the preprint server for biology · 2025Article
- Circuit-selective pharmacological targeting of prefrontal cortex-projecting locus coeruleus neurons drives antinociception.Cell reports · 2025Article
- Stress reactivity is modulated by cannabinoid type-1 receptors in norepinephrine and epinephrine neurons in a context-dependent manner.Neuroscience · 2025Article
- Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system.Pharmacological reviews · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Andrew T Luskin *Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Li Li *Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6131-4394
Xiaonan FuCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Madison M MartinDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2663-7865
Kelsey BarcombDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-4050-0566
Kasey S GirvenDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Taylor BlackburnDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Bailey A WellsDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0009-0000-9941-8383
Sarah T ThaiDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3538-4791
Esther M LiDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Akshay N RanaDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Rhiana C SimonDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Li SunCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Lei GaoDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Alexandria D MurryCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.
Sam A GoldenCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2104-2272
Garret D StuberDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1730-4855
Christopher P FordDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.
Liangcai GuCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8232-6025
Michael R BruchasDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA. mbruchas@uw.edu.ORCID 0000-0003-4713-7816
Funding
University of Washington Center of Excellence in Opioid Addiction ResearchP30DA048736 · NIDA · UNIVERSITY OF WASHINGTON · PI Charles Chavkin · 2019 to 2026
$13.0MTRAINING IN THE MOLECULAR PHARMACOLOGY OF ABUSED DRUGST32DA007278 · NIDA · UNIVERSITY OF WASHINGTON · PI Susan Marie Ferguson, Paul E. M. Phillips · 1993 to 2026
$9.8MSystems and Molecular Neurobiology Training ProgramT32GM008151 · NIGMS · WASHINGTON UNIVERSITY · PI SNYDER, LAWRENCE H · 1985 to 2019
$6.5MDecoding Locus Coeruleus Neural Circuits and Signaling In Negative AffectR01MH112355 · NIMH · WASHINGTON UNIVERSITY · PI Michael R. Bruchas · 2016 to 2026
$5.3MNeural circuit elements that orchestrate cue-reward associationsR37DA032750 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Garret D Stuber · 2017 to 2026
$4.5MLateral Hypothalamic Circuits for Feeding and ReinforcementR01DA038168 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STUBER, GARRET D · 2014 to 2025
$4.0MEncoding Dopamine Signals in the Mesolimbic SystemR01DA035821 · NIDA · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2013 to 2023
$3.5MTranscriptional, functional, and circuit profiling at single cell resolution of neuronal ensembles engaged by heroin relapseR01DA054317 · NIDA · UNIVERSITY OF WASHINGTON · PI FERGUSON, SUSAN MARIE, STUBER, GARRET D · 2021 to 2025
$2.7MUniversity of Washington Significant Opportunities in Addiction Research (UW-SOAR) Neuroscience Doctoral Readiness ProgramR25DA057786 · NIDA · UNIVERSITY OF WASHINGTON · PI FERGUSON, SUSAN MARIE, PHILLIPS, PAUL E. M. · 2022 to 2025
$1.4MOptopharmacology and Sensors for Dissecting Opioid Action In VivoR61DA051489 · NIDA · UNIVERSITY OF WASHINGTON · PI BRUCHAS, MICHAEL R., GU, LIANGCAI · 2020 to 2022
$1.2MPIXEL-seq-based spatial, multi-omic profiling for senescent cell mapping with single-cell resolutionUG3CA268096 · NCI · UNIVERSITY OF WASHINGTON · PI GU, LIANGCAI · 2021 to 2022
$1.1MOptopharmacology and Sensors for Dissecting Opioid Action In VivoR33DA051489 · NIDA · UNIVERSITY OF WASHINGTON · PI BRUCHAS, MICHAEL R., GU, LIANGCAI · 2023 to 2024
$1.0MNCI NIH HHS UG3 CA268096NIDA NIH HHS K99 DA053336NIDA NIH HHS P30 DA048736NIDA NIH HHS R00 DA045662NIDA NIH HHS R00 DA053336NIDA NIH HHS R01 DA035821NIDA NIH HHS R01 DA038168NIDA NIH HHS R01 DA054317NIDA NIH HHS R25 DA057786NIDA NIH HHS R33 DA051489NIDA NIH HHS R37 DA032750NIDA NIH HHS R61 DA051489NIDA NIH HHS T32 DA007278NIDA NIH HHS UG3 DA053802NIGMS NIH HHS T32 GM008151NIMH NIH HHS F31 MH117931NIMH NIH HHS F31 MH122033NIMH NIH HHS F31 MH136670NIMH NIH HHS R01 MH112355NIMH NIH HHS R21 MH123085NIMH NIH HHS R41 MH130299
Abstract
As the primary source of noradrenaline in the brain, the locus coeruleus (LC) regulates arousal, avoidance and stress responses
Indexed as
ArousalExploratory BehaviorGABAergic NeuronsLocus CoeruleusNeuronsAnimalsAvoidance LearningFemaleMaleMiceMice, Inbred C57BLNorepinephrineSingle-Cell AnalysisTranscriptomeNorepinephrine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.