Evidence map›Paper›PMID 40335694›Full record

ArticleNature2025

Chromatin loops are an ancestral hallmark of the animal regulatory genome.

Iana V Kim, Cristina Navarrete, Xavier Grau-Bové, Marta Iglesias, Anamaria Elek, Grygoriy Zolotarov, Nikolai S Bykov, Sean A Montgomery, Ewa Ksiezopolska, Didac Cañas-Armenteros and 7 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. MACRO-MOLECULAR CROWDING FAVORS WRITHE IN UNWOUND DNA.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Decoding cnidarian cell type gene regulation.Nature ecology & evolution · 2026
    Article
  16. High-throughputbioRxiv : the preprint server for biology · 2025
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Iana V KimCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. iana.kim@crg.eu.ORCID 0000-0003-4997-1871
Cristina Navarrete *Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Xavier Grau-Bové *Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Marta IglesiasCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0003-1757-7343
Anamaria ElekCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0002-3938-2494
Grygoriy ZolotarovCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Nikolai S BykovCentre Nacional d'Anàlisis Genòmic (CNAG), Barcelona, Spain.ORCID 0000-0002-6321-487X
Sean A MontgomeryCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID 0000-0003-1680-4858
Ewa KsiezopolskaCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Didac Cañas-ArmenterosCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Joan J Soto-AngelMichael Sars Centre, University of Bergen, Bergen, Norway.ORCID 0000-0002-9132-4822
Sally P LeysDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-9268-2181
Pawel BurkhardtMichael Sars Centre, University of Bergen, Bergen, Norway.ORCID 0000-0001-9826-057X
Hiroshi SugaDepartment of Life and Environmental Sciences, Faculty of Bioresource Sciences, Prefectural University of Hiroshima, Shobara, Japan.ORCID 0000-0003-1795-2174
Alex de MendozaSchool of Biological and Behavioral Sciences, Queen Mary University of London, London, UK.ORCID 0000-0002-6441-6529
Marc A Marti-RenomCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Arnau Sebé-PedrósCentre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. arnau.sebe@crg.eu.ORCID 0000-0002-9896-9746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In bilaterian animals, gene regulation is shaped by a combination of linear and spatial regulatory information. Regulatory elements along the genome are integrated into gene regulatory landscapes through chromatin compartmentalization

Indexed as

ChromatinEvolution, MolecularGene Expression RegulationGenomeAnimalsCnidariaCtenophoraEnhancer Elements, GeneticPlacozoaPromoter Regions, GeneticChromatin

Identifiers

PMID40335694
PMCPMC12221973

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.