Evidence map›Paper›PMID 40335692›Full record

ArticleNature2025

Striatum supports fast learning but not memory recall.

Kimberly Reinhold, Marci Iadarola, Shi Tang, Annabel Chang, Whitney Kuwamoto, Madeline A Albanese, Senmiao Sun, Richard Hakim, Joshua Zimmer, Wengang Wang and 1 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Long-term Learning Induces Plastic Changes in Frontostriatal Circuits.bioRxiv : the preprint server for biology · 2026
    Article
  5. A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
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  13. Article
  14. Article
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  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kimberly ReinholdDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Marci IadarolaDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6203-3631
Shi TangDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Annabel ChangDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0009-0002-1536-3640
Whitney KuwamotoDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Madeline A AlbaneseDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Senmiao SunDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5188-4374
Richard HakimDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Joshua ZimmerDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Wengang WangDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4659-6909
Bernardo L SabatiniDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA. bernardo_sabatini@hms.harvard.edu.ORCID 0000-0003-0095-9177

Funding

Towards a Unified Framework for Dopamine Signaling in the StriatumU19NS113201 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2019 to 2023
$18.7M
Action and interaction of ionotropic and metabotropic neurotransmissionR37NS046579 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2018 to 2024
$4.6M
Action and Interaction of Neurotransmitters and NeuromodulatorsR35NS137336 · NINDS · HARVARD MEDICAL SCHOOL · PI Bernardo L Sabatini · 2024 to 2026
$2.1M
Distributed Neural Activity Patterns Underlying Practice-Based LearningK99MH127471 · NIMH · HARVARD MEDICAL SCHOOL · PI REINHOLD, KIMBERLY · 2022 to 2024
$264k
NIMH NIH HHS K99 MH127471NINDS NIH HHS R35 NS137336NINDS NIH HHS R37 NS046579NINDS NIH HHS U19 NS113201
6 · The paper itself

Abstract

Animals learn to carry out motor actions in specific sensory contexts to achieve goals. The striatum has been implicated in producing sensory-motor associations

Indexed as

Corpus StriatumLearningMental RecallAnimalsCuesFemaleForelimbMaleMemory, Long-TermMiceMice, Inbred C57BLNeuronsOptogeneticsTime FactorsVisual Cortex

Identifiers

PMID40335692
PMCPMC12244412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.