Evidence map›Paper›PMID 40335674›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Screening of key active ingredients of Fuyuan Shenghua granules for the treatment of medical abortion using ingredient-target interaction and pharmacokinetics.

Qi-Qiang Zhang, Mei-Xiang Yu, Xue-Mei Di, Xiang Cao, Ai-Jia Zhao, Yong-Hong Nie, Wen Shuai, Qin-Hua Zhang, Hai Zhang

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi-Qiang Zhang *Department of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Mei-Xiang Yu *Department of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xue-Mei Di *Department of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Xiang CaoDepartment of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Ai-Jia ZhaoDepartment of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yong-Hong NieShanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Wen ShuaiShanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Qin-Hua ZhangDepartment of Obstetrics and Gynecology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200120, China. 13601983371@163.com.
Hai ZhangDepartment of Pharmacy, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. zhxdks2005@126.com.

Funding

the Shanghai Science and Technology Innovation Action Plan 22S21903000the Talent Program of the Shanghai Municipal Health Commission 2022XD041
6 · The paper itself

Abstract

Fuyuan Shenghua granule (FYSHG) is a clinical herbal formula adapted for medical abortion as an adjuvant treatment. This study aimed to screen the key active ingredients of FYSHG in treating medical abortion in vivo using ingredient-protein interaction and pharmacokinetics. The main ingredients of FYSHG absorbed in the blood were identified through UHPLC-Q-TOF/MS. An ingredient-target interaction network was constructed and analyzed to screen the key active ingredients of FYSHG in the treatment of medical abortion. The network was validated via molecular docking in silico and surface plasmon resonance (SPR) assays in vitro. Finally, the concentration was analyzed via UHPLC‒MS/MS, and pharmacokinetic characteristics including AUC, C

Indexed as

Abortion, InducedDrugs, Chinese HerbalAnimalsChromatography, High Pressure LiquidFemaleMolecular Docking SimulationPregnancyRats, Sprague-DawleyTandem Mass SpectrometryDrugs, Chinese HerbalFuyuan Shenghua granuleKey active ingredientMedical abortionPharmacokinetic characteristics

Identifiers

PMID40335674

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.