Evidence map›Paper›PMID 40335646›Full record

ArticleGenes and immunity2025

A Golgi apparatus-related signature predicts the immune microenvironment and prognosis of gastric cancer.

Changlei Wu, Liang Sun, Wenjie Zhu, Chao Huang, Zhengming Zhu, Zitao Liu

Abstract read
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In one paragraph

Article in Genes and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Changlei Wu *Department of Gastrointestinal Surgery, The Second Afffliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Liang Sun *Department of Gastrointestinal Surgery, The Second Afffliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Wenjie Zhu *Department of Gastrointestinal Surgery, The Second Afffliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Chao HuangDepartment of Gastrointestinal Surgery, The Second Afffliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China.
Zhengming ZhuDepartment of Gastrointestinal Surgery, The Second Afffliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China. zhengmingzhu28@126.com.ORCID 0009-0004-8184-6928
Zitao LiuDepartment of Gastrointestinal Surgery, The Second Afffliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China. zitaoliu28@163.com.ORCID 0000-0001-7319-342X

Funding

Jiangxi Provincial Department of Science and Technology (Department of Science and Technology, Jiangxi Province) 20232ACB206032Jiangxi Provincial Department of Science and Technology (Department of Science and Technology, Jiangxi Province) 20232BAB216088
6 · The paper itself

Abstract

In recent years, numerous studies have provided evidence of the involvement of the Golgi apparatus (GA) in various stages of cancer development. Nonetheless, the specific impact of GA-related characteristics on gastric cancer (GC) progression remains ambiguous. We utilized LASSO and multivariate COX regression methods to develop a GA-associated risk score (GARS). The GARS is constructed from seven signature genes, which are highly expressed in tumors. In our research, we have found that GARS is an effective indicator for predicting the prognosis of GC, chemotherapy sensitivity, and immune therapy response. Patients in the low GARS group exhibit characteristics such as a good prognosis, increased sensitivity to immune therapy, 5-fluorouracil, and paclitaxel. Finally, our experimental results confirm that knocking down F2R significantly reduces the proliferation and migration abilities of GC cells. This study highlights the importance of GA characteristics in predicting the prognosis of GC and in developing personalized treatment strategies. The experimental findings on F2R offer valuable theoretical insights for the diagnosis and management of GC.

Indexed as

Golgi ApparatusStomach NeoplasmsTumor MicroenvironmentBiomarkers, TumorCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, Tumor

Identifiers

PMID40335646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.