ArticleScientific reports2025
Enhanced classification of tinnitus patients using EEG microstates and deep learning techniques.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Enhancing corporate bankruptcy prediction and customer relationship sustainability through CNN-based financial feature transformation.Scientific reports · 2026Article
- EEG Spectral Analysis of Tinnitus Sound Therapy: Meta-Analysis.Journal of otology · 2026Review
- Whole-brain functional activity and connectivity for the classification of subjective tinnitus: a machine learning study.Frontiers in neurology · 2026Article
- The necessity of multimodal feedback for learning effective pedagogical policies with reinforcement learning.Scientific reports · 2025Article
- EEG entropy modulation as a biomarker of emotion regulation and resilience.IBRO neuroscience reports · 2025Review
- Resting state EEG reveals no reliable biomarkers of tinnitus laterality.Scientific reports · 2025Article
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Authors and funding
7 authors.
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Abstract
This study aims to deepen the understanding and classification of tinnitus through a comprehensive analysis of EEG signals utilizing innovative microstate analysis techniques and cutting-edge machine learning approaches. EEG data were collected from two datasets: a primary dataset with 36 participants (16 healthy, 20 tinnitus) and a public dataset with 37 participants (15 healthy, 22 tinnitus). Signals were decomposed into five frequency bands (delta, theta, alpha, beta, gamma) using Daubechies 4 wavelet at five decomposition levels. Microstate features (Duration, Occurrence, Mean Global Field Power, and Coverage) were extracted across four microstate configurations (4-state to 7-state) under both eyes-closed and eyes-open conditions. Classification was performed using SVM, Decision Tree, Random Forest, and Deep Neural Networks. Additionally, pre-trained models (VGG16, ResNet50, Xception) were used with a novel feature-to-image transformation approach for validation. Analysis revealed significant alterations in beta band microstates, with microstate A showing increased duration (+ 7.8% to + 11.2%) and microstate B showing decreased duration (- 9.0% to - 13.8%) in tinnitus patients. Occurrence rates were markedly elevated (~ 28-29% higher) in the tinnitus group. Transition probability analysis identified distinctive patterns between groups, with the most pronounced differences observed in gamma band (6-state configuration) during eyes-closed condition (healthy: F → B = 0.143; tinnitus: C → D = 0.153) and beta band (7-state configuration) also during eyes-closed condition (healthy: E → A = 0.091; tinnitus: C → E = 0.082). In the eyes-open condition, gamma band with 7 microstates showed substantial differences in transition patterns (healthy: E → A = 0.149; tinnitus: C → G = 0.157). Classification performance was exceptional, with DNN achieving 100% accuracy in the gamma frequency band during eyes-open condition with 5-state configuration. Frequency band analysis demonstrated that gamma band performed best for open eyes (99.89% accuracy) and beta band excelled for closed eyes (96.46% accuracy). Validation with pre-trained models showed ResNet50 with SVM classifier using 6-state configurations provided optimal discrimination (100% accuracy). EEG microstate dynamics in beta and gamma bands serve as reliable markers for distinguishing tinnitus patients. These findings provide insights into tinnitus-related neural alterations and highlight microstate analysis as a potential objective diagnostic tool for guiding personalized neuromodulation therapies.
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