Evidence map›Paper›PMID 40335575›Full record

ArticleScientific reports2025

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson's disease revealed by in vivo PET imaging.

Teresa Delgado-Goñi, Natalie Connor-Robson, Milena Cioroch, Stephen Paisey, Christopher Marshall, Emma L Lane, David Hauton, James McCullagh, Peter J Magill, Stephanie J Cragg and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Teresa Delgado-Goñi *Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Natalie Connor-Robson *Oxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Milena CiorochOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Stephen PaiseyWales Research and Diagnostic PET Imaging Centre (PETIC), School of Medicine, Heath Park, Cardiff University, Cardiff, Wales, UK.
Christopher MarshallWales Research and Diagnostic PET Imaging Centre (PETIC), School of Medicine, Heath Park, Cardiff University, Cardiff, Wales, UK.
Emma L LaneSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, UK.
David HautonDepartment of Chemistry, University of Oxford, Oxford, UK.
James McCullaghDepartment of Chemistry, University of Oxford, Oxford, UK.
Peter J MagillOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Stephanie J CraggOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Clare E MackayOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Richard Wade-MartinsOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK.
Johannes C KleinOxford Parkinson's Disease Centre (OPDC), University of Oxford, Oxford, UK. johannes.klein@ndcn.ox.ac.uk.

Funding

Medical Research Council MC_UU_12024/2Wellcome Trust
6 · The paper itself

Abstract

We conducted PET imaging with [

Indexed as

Corpus StriatumLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseasePositron-Emission TomographyReceptors, Dopamine D2AnimalsBenzamidesDisease Models, AnimalDopamineHumansMaleMutationRatsRats, TransgenicUp-RegulationBenzamidesDopaminefallyprideLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Receptors, Dopamine D2[18F]fallypride[18F]FDOPALRRK2Parkinson’s diseasePETRat

Identifiers

PMID40335575
PMCPMC12059153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.