ArticleNature communications2025
Immunomodulatory multifunctional janus collagen-based membrane for advanced bone regeneration.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Porcelain-clay-inspired microsphere hydrogel bioink facilitates bone regeneration via immune-osteogenic regulation.Bioactive materials · 2027Article
- Hypoxia-programmed apoptotic-mimetic M2 macrophage-derived small extracellular vesicles for hydrogel-mediated immunoregenerative bone repair.Materials today. Bio · 2026Article
- Immunomodulatory cytoskeleton of bionic periosteum affects mitochondrial dynamics to promote osteogenesis.Bioactive materials · 2026Article
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Article
- Janus microneedles enabling orderly vitiligo treatment through spatiotemporal sequential promoting melanogenesis to transferAsian journal of pharmaceutical sciences · 2026Article
- Synergistic osteogenesis, angiogenesis, and immune reprogramming by a metal-phenolic functionalized electrospun fibrous membrane for alveolar bone regeneration.Materials today. Bio · 2026Article
- A novel PCL fiber membrane with a gradient structure for guided bone regeneration.RSC advances · 2026Article
- Tannic acid-assisted mechanical training transforms natural hydrogels into robust and bioactive membranes for guided bone regeneration.Materials today. Bio · 2026Article
- Synergistic effects of collagen membrane and mineral trioxide aggregate on odontogenic differentiation and mineralization of human dental pulp stem cells: an in vitro study.BMC oral health · 2026Article
- Electro-controlled assembled of biphasic guided bone regeneration membrane for healing of diabetic periodontal bone defects.Journal of nanobiotechnology · 2026Article
- Hydrogel-Based Immunomodulatory Strategies for Infected Bone Defects Regeneration: Remodeling the Osteoimmune Microenvironment and Future Perspectives.International journal of nanomedicine · 2026Review
- Anion-Dependent Layered Double Hydroxide-Reinforced Gelatin Methacryloyl Hydrogels for Osteoimmunomodulation and Bone Regeneration.International journal of nanomedicine · 2026Article
- Association between fibrinogen concentration and nonunion in fracture patients.Frontiers in surgery · 2026Article
- Janus Membranes as Multifunctional Nanostructures for Bone Defect Repair: Advances, Challenges, and Clinical Translation.International journal of nanomedicine · 2026Review
- Senescence of bone marrow mesenchymal stromal cells: a narrative review of mechanisms, functional consequences, and rejuvenation strategies for age-related disorders.Stem cell research & therapy · 2025Review
- Acellular fishbone scaffolds loaded with bone marrow mesenchymal stem cell-derived exosomes for bone defect repairing.Journal of nanobiotechnology · 2025Article
- Synergetic regulation of osteoimmune microenvironment and osteogenesis by decellularized amnion membrane for guided bone regeneration.Materials today. Bio · 2025Article
- A Collagen Membrane Pretreated with Citrate Promotes Collagen Mineralization and Bone Regeneration.Journal of functional biomaterials · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Guided bone regeneration (GBR) is a standard therapy for treating bone defects, with collagen-based barrier membranes widely used clinically. However, these membranes face challenges like poor mechanical properties, early bacterial invasion and immunomodulation deficiency, potentially risking GBR failure. Orchestrating macrophage activation and controlling their M1 or M2 polarization are effective strategies for bone repair. Here, we present a Janus collagen-based barrier membrane with immunomodulation. The porous layer promotes direct osteogenic differentiation and inward growth of osteoblasts. The dense layer prevents invasion of soft tissue into bone defects and protects bone defects from bacterial infection. The membrane also enhances rat bone marrow-derived mesenchymal stem cell infiltration, proliferation, and osteogenic differentiation by regulating the immune microenvironment, demonstrating superior bone regeneration compared to the commercial Bio-Gide® membrane. Overall, the Janus collagen-based membrane reduces tissue inflammation and fosters an osteoimmune environment conducive to new bone formation, offering effective material design for advanced GBR technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.