ArticleNature communications2025
Habenula contributions to negative self-cognitions.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Habenula-ventral tegmental area functional coupling and risk aversion in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Self-related cognitions are integral to personal identity and psychological wellbeing. Persistent engagement with negative self-cognitions can precipitate mental ill health; whereas the ability to restructure them is protective. Here, we leverage ultra-high field 7T fMRI and dynamic causal modelling to characterise a negative self-cognition network centred on the habenula - a small midbrain region linked to the encoding of punishment and negative outcomes. We model habenula effective connectivity in a discovery sample of healthy young adults (n = 45) and in a replication cohort (n = 56) using a cognitive restructuring task during which participants repeated or restructured negative self-cognitions. The restructuring of negative self-cognitions elicits an excitatory effect from the habenula to the posterior orbitofrontal cortex that is reliably observed across both samples. Furthermore, we identify an excitatory effect of the habenula on the posterior cingulate cortex during both the repeating and restructuring of self-cognitions. Our study provides evidence demonstrating the habenula's contribution to processing self-cognitions. These findings yield unique insights into habenula's function beyond processing external reward/punishment to include abstract internal experiences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.