ArticleNature communications2025
Tinnitus risk factors and its evolution over time.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Tinnitus Phenotypes and Their Response to the Enriched Acoustic Environment (EAE) Treatment.Brain sciences · 2026Article
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Otological conditions and autism spectrum disorder in Medicaid beneficiaries aged 1 to 20 years: a cross-sectional study.BMC pediatrics · 2026Article
- Associations of Dietary Factors, Body Mass Index, and Physical Activity with Tinnitus: A Scoping Review.Journal of clinical medicine · 2026Review
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Tinnitus and Reactions to Tinnitus: A Cross-Sectional Survey Across Different Tinnitus Durations.Audiology research · 2026Article
- [Research progress on the mechanism of auditory center remodeling and clinical intervention strategies in presbycusis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- Tinnitus perception is linked to arousal dysfunction.iScience · 2026Article
- Tinnitus and occupational noise exposure among informal generator technicians in Nigeria: A pilot cohort study.PLOS global public health · 2026Article
- Development and Validation of a Nomogram to Identify and Predict High-Distress Psychosocial Phenotypes in Tinnitus Patients: A Latent Profile Analysis.Psychology research and behavior management · 2026Article
- Tinnitus constancy and self-reported severe headache or migraine symptoms in peri- and postmenopausal women: a statistical modeling and machine learning analysis.European journal of medical research · 2025Observational
- Development and comparison of machine learning models for predicting moderate-to-severe tinnitus in patients with hearing loss.Frontiers in neurology · 2025Article
- Identifying psychological and clinical risk factors for moderate-to-severe tinnitus in older patients with hearing loss: a multivariable prediction model.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Subjective tinnitus is an auditory percept unrelated to external sounds, for which the limited understanding of its risk factors complicates the prevention and management. In this study, we train two distinct machine learning models to predict tinnitus presence (how often individuals perceive tinnitus) and severity separately using socio-demographic, psychological, and health-related predictors with the UK Biobank dataset (192,993 participants, 41,042 with tinnitus). We show that hearing health was the primary risk factor of both presence and severity, while mood, neuroticism, and sleep predicted severity. The severity model accurately predicts tinnitus progression over nine years, with a large effect size for individuals developing severe tinnitus (Cohen's d = 1.3, ROC = 0.78). This result is validated on 463 individuals from the Tinnitus Research Initiative database. We simplify the severity model to a six-item clinical questionnaire that detects individuals at risk of severe tinnitus, for which early supportive care would be crucial.
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