Evidence map›Paper›PMID 40335118›Full record

SynthesisSaudi medical journal2025

Breast cancer incidence after hormonal treatment for infertility: A meta-analysis of population-based studies.

Amal Y Zaman, Lama S Alrefai, Dorar F Alharbi, Rahaf A Khurmi, Leen M Abuanq, Ajyal A Aljohani, Ibrahim M Dighriri, Nada Elnugomi

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amal Y ZamanFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Lama S AlrefaiFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Dorar F AlharbiFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Rahaf A KhurmiFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Leen M AbuanqFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Ajyal A AljohaniFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Ibrahim M DighririFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
Nada ElnugomiFrom the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0003-3670-4432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo comprehensively understand the relationship between infertility medications and the risk of breast cancer (BC) in females.

methodsRelevant literature search using different databases (PubMed, The Cochrane Library, Embase, Scopus, and Web of Sciences) following preferred reporting items for systematic reviews and meta-analyses guidelines was carried out from 2003-2023. Population-based studies comparing the incidence of BC after hormonal fertility treatment and a control group were included. In addition, random and fixed effect models were used to carry out meta-analyses.

resultsA total of 15 studies involving 92,555 women were included in this review. The pooled analysis using risk ratios (RRs) showed no evidence of increased BC risk associated with hormonal fertility medications (RR=1.00, 95% confidence interval [CI]: [0.97-1.02],

conclusionThis meta-analysis found no evidence of increased risk of BC following hormonal infertility treatment. However, the results should be illustrated cautiously, given the heterogeneity between studies.

Indexed as

Breast NeoplasmsFertility Agents, FemaleInfertility, FemaleFemaleHumansIncidenceFertility Agents, Femalebreast cancerhormonal fertility treatmentinfertility

Identifiers

PMID40335118
PMCPMC12074055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.