ArticleSaudi medical journal2025
Exploring hypothyroidism's effects on lipid profiles: Evidence of metabolic consequences in subclinical disease.
Article in Saudi medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Combined Treatment of Type 2 Diabetes and Hypothyroidism: Impact of Oral Semaglutide and Levothyroxine on Cardiometabolic and Thyroid Parameters: A 6-Month Comparative Study.Epidemiologia (Basel, Switzerland) · 2026Article
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Abstract
objectivesTo investigate the association between thyroid-stimulating hormone (TSH) levels and lipid profiles in patients with subclinical hypothyroidism (SCH) to assess the metabolic risks.
methodsThis retrospective study included patients diagnosed with SCH between January 2023 and August 2024. Thyroid function markers (TSH, free triiodothyronine, and free thyroxine levels) and lipid profiles (total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglyceride levels) were assessed in 137 patients.
resultsThe mean age of patients was 44.6±13.6 years, with 86.1% being female and 92.7% having dyslipidemia. Thyroid-stimulating hormone levels were correlated with serum creatinine levels (r=0.27,
conclusionSubclinical hypothyroidism impairs lipid metabolism, particularly in females with high BMI. Triglycerides suppress free thyroxine levels, whereas elevated TSH levels correlate with increased creatinine levels. Our findings suggest a potential relationship between SCH and lipid alterations, warranting further investigation into targeted lipid management in these patients.
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