ArticleEnvironmental research2025
Low-level arsenic exposure, childhood neighborhood disadvantage, and executive functions in adolescents from Montevideo, Uruguay.
Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association of Blood Arsenic Concentrations with Lipid Markers in Uruguayan Adolescents: Exploring Effect Modification by Body Mass Index and Sex.Exposure and health · 2026Article
- Exposure to a mixture of four metals and associations with urinary oxidative stress biomarkers in Uruguayan adolescents.Journal of environmental exposure assessment · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionLow-level arsenic (As) exposure is linked to cognitive deficits, but its impact on specific executive functions (EF) in adolescents is not well understood. Additionally, neighborhood socioeconomic context may interact with As exposure to influence cognitive outcomes. This study examines associations between blood As levels, neighborhood disadvantage, and EF performance in adolescents from Montevideo, Uruguay.
methodsWe analyzed data from 344 adolescents in the Salud Ambiental Montevideo (SAM) cohort, where blood As levels were measured at two time points, with values averaged and log2-transformed for analysis. EFs, including working memory, inhibitory control, cognitive flexibility, and fluid cognition, were assessed using the NIH Cognitive Toolbox. Neighborhood disadvantage (ND) was represented as a factor encompassing sociodemographic indicators. Multiple imputation was used to handle missing data, and linear regression models tested associations between As exposure, EFs, and potential interactions with ND. Furthermore, we explored effect modification by age (young adolescents <11.6 years, older adolescents ≥11.6 years).
resultsBased on multivariable models, there was no evidence for an association between blood As and EFs or fluid cognition or of interactions with neighborhood disadvantage. Exploratory analyses revealed evidence of effect modification by age, with inverse associations between As exposure and inhibitory control and working memory at younger ages.
conclusionThere was no evidence for an association between low-level blood As and EFs in adolescents overall, but age-related susceptibility to As was suggested for younger ages. Further research on low-level As exposure in adolescents is needed to better understand critical windows of susceptibility and socioeconomic contexts for neurotoxic effects of As.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.