Evidence map›Paper›PMID 40334844›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2025

Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.

Bhavya Kapse, Rashmi Prava Mohanty, Michael Wax, Ying Gao, Lily Tran, Paul J Wolters, Matteo Pellegrini, Jonathan P Singer, John R Greenland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bhavya KapseDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Rashmi Prava MohantyDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Michael WaxDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Ying GaoDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Lily TranDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Paul J WoltersDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
Matteo PellegriniDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA; Institute for Quantitative and Computational Biosciences - The Collaboratory, University of California Los Angeles, Los Angeles, California, USA.
Jonathan P SingerDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA.
John R GreenlandDepartment of Medicine, University of California, San Francisco, San Francisco, California, USA; Medical Service, Veterans Affairs Health Care System, San Francisco, California, USA. Electronic address: John.Greenland@ucsf.edu.

Funding

Long Term Follow up of the Lung Transplant Outcomes Group CohortU01HL145435 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHRISTIE, JASON D, PALMER, SCOTT M · 2019 to 2025
$10.2M
Lung Remodeling Mediated by Telomere Dysfunction in Alveolar Type II CellsR01HL139897 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Paul j WOLTERS · 2018 to 2026
$5.5M
Frailty and patient centered outcomes in candidates for lung transplantationR01HL134851 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2017 to 2021
$3.4M
Telomere Dysfunction as a cause of Chronic Lung Allograft DysfunctionR01HL151552 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GREENLAND, JOHN · 2020 to 2024
$1.6M
CSRD VA I01 CX002011NHLBI NIH HHS R01 HL134851NHLBI NIH HHS R01 HL139897NHLBI NIH HHS R01 HL151552NHLBI NIH HHS U01 HL145435
6 · The paper itself

Abstract

Frailty is a syndrome of vulnerability to stressors linked to worse outcomes before and after lung transplantation. However, the biological basis of this association is unknown. Biological correlates of aging include epigenetic reprograming, chronic inflammation, telomere dysfunction, and anemia. We hypothesized that these aging-associated biological processes would be associated with frailty in lung transplant recipients. In a nested case-control study, we compared 43 lung transplant recipients who were frail pretransplant and posttransplant with 43 nonfrail matched controls. We quantified peripheral blood leukocyte epigenetic aging (Horvath) and longevity (GrimAge) clocks, telomere length, cytokine profiles, and hemoglobin before transplant. Epigenetic clocks were correlated with age but not frailty. However, we observed hypermethylation of multiple gene pathways, including hedgehog signaling and angiogenesis, and associated decreased levels of plasma cytokines in frail recipients. Frailty was also associated with telomere dysfunction and anemia. Overall, telomere dysfunction and anemia of chronic disease were most linked to frailty in this cohort, whereas epigenetic aging and chronic inflammation were not. Understanding the heterogeneity of aging syndromes may help target interventions in frail lung transplant recipients.

Indexed as

AnemiaEpigenesis, GeneticFrailtyLung TransplantationTelomereAdultAgedCase-Control StudiesDNA MethylationFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRisk Factorsanemiaepigenetic agefrailtylung transplanttelomere

Identifiers

PMID40334844
PMCPMC12798830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.