ArticleGait & posture2025
Assessment of hip joint mechanics during walking in people with Marfan syndrome.
Article in Gait & posture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sex-dependent alterations of the femoral geometry in a mouse model of Marfan syndrome.JBMR plus · 2026Article
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8 authors.
Funding
Abstract
backgroundMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder and is associated with muscle dysfunction. Individuals with MFS exhibit quadriceps weakness, hip joint pain, and an increased incidence of hip osteoarthritis (OA) compared to the general population, yet the underlying biomechanical factors associated with these poor hip-related outcomes are not well understood. RESEARCH QUESTION: The purpose of this study was to assess the effects of MFS on gait mechanics and to determine the relationship of gait mechanics with hip-related outcomes within the MFS group.
methodsEighteen people with MFS and 18 healthy, asymptomatic controls underwent 3D gait analysis. All study participants completed the Hip disability and Osteoarthritis Outcome Survey (HOOS) to obtain patient reported outcomes. (PROs). Between group differences in demographics, HOOS scores, and gait mechanics were analyzed via independent t-tests, a Kruskal-Wallis test, and a multi variate analysis of covariance while adjusting for age, respectively. A Spearman's rank-order correlation was used to assess the relationship between HOOS sub-scores and kinetic and kinematic parameters.
resultsThe MFS cohort was significantly older than the control cohort and ambulated with altered sagittal plane pelvis, knee and ankle kinematics as well as ankle kinetics. The MFS cohort ambulated with a higher hip transverse plane range of motion, hip extensor moment impulse (HEMI), peak hip abduction moments and hip abduction moment impulse. The MFS group also exhibited a higher hip internal rotation moment (HIRM) compared to the control group. The MFS cohort also self-reported worse hip-related PRO. Higher HIRM and HEMI were associated with worse hip-related pain and QOL within the MFS group. SIGNIFICANCE: These results suggest that people with MFS walk with altered pelvic and lower extremity joint mechanics which may be associated with the higher incidence rates of hip OA and poor hip-related PRO observed in the MFS population.
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