Evidence map›Paper›PMID 40334210›Full record

ArticlePloS one2025

Nerve injury induces pain hypersensitivity and anxiety-related behaviours and is associated with amygdala activation in male mice.

Siyuan Tong, Yuerong Chen, Zonglin Wu, Linbao Wang, Yuxin Wei, Xirui Wang, Yuanyuan Wu

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PubMed Full text at PMC Publisher
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Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siyuan TongKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0001-6517-6208
Yuerong ChenKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Zonglin WuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Linbao WangKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0009-0006-5016-4312
Yuxin WeiKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Xirui WangKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Yuanyuan WuKey Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.ORCID 0000-0001-8884-0802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuropathic pain is a common health problem, often accompanied by anxiety. The amygdala plays a crucial role in emotional processing and the basolateral amygdala (BLA) and the central amygdala (CeA) are primary components of the amygdala. The c-Fos is considered indicative of neuronal activation. We studied whether BLA and CeA are activated and their internal activation when chronic neuralgia occurs.

methodsThe spared nerve injury (SNI) model was employed for this investigation. Mechanical paw withdrawal thresholds (PWTs) were utilized for assessing pain hypersensitivity, followed by observation of anxiety-like behaviors using the elevated plus maze test (EPMT) and the open field test (OFT). The c-Fos in BLA and CeA were measured by immunofluorescence staining.

resultsWe found that SNI mice exhibit pain hypersensitivity and anxiety-like behaviors. The expression of c-Fos in the BLA and CeA was upregulated in SNI mice. Besides, there were spatial differences in c-Fos expression between BLA and CeA.

conclusionThe BLA and CeA showed activation in chronic pain and associated anxiety, and there were spatial differences in this activation. Targeting the amygdala may hold promise for treating chronic nerve pain with anxiety-like behaviors.

Indexed as

AmygdalaAnxietyCentral Amygdaloid NucleusHyperalgesiaNeuralgiaAnimalsBasolateral Nuclear ComplexBehavior, AnimalDisease Models, AnimalMaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-fos

Identifiers

PMID40334210
PMCPMC12058149

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.