SynthesisPloS one2025
Gender differences in the impact of fatigue on lower limb landing biomechanics and their association with anterior cruciate ligament (ACL) injuries: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Is there a difference in knee biomechanics due to fatigue of the quadriceps versus hamstrings during landing on a single limb? a randomized comparative laboratory study.BMC sports science, medicine & rehabilitation · 2026Article
- Neuromuscular Characteristics of Female Futsal Players: A Systematic Review.Sports (Basel, Switzerland) · 2026Review
- Comparative analysis of isokinetic ratios between hamstrings and quadriceps in wrestlers: Resting state versus post-fatigue evaluation.PloS one · 2026Article
- Task specific effects of fatigue on lower limb muscle synergies during single and double leg drop jumps in female athletes.Frontiers in physiology · 2026Article
- Combined Reconstruction of the Anterior Cruciate Ligament, Anterior Oblique Ligament, and Medial Collateral Ligament of the Knee: Surgical Technique Description.Arthroscopy techniques · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis meta-analysis examines the impact of neuromuscular fatigue on gender differences in lower limb landing biomechanics and its correlation with ACL injury risk.
methodsA comprehensive search was conducted in PubMed, Scopus, Web of Science, Embase, and the Cochrane Library up to March 2024.
resultsFourteen studies were included, averaging a quality score of 6.79; nine were high quality. Key findings: males showed a significant increase in knee flexion angle at initial contact (effect size -1.23), but females did not (-0.25). Both genders had significant changes in hip external rotation (males: 1.35, females: 1.20). Ankle peak dorsiflexion angle increased (-1.69) with no gender differences. Peak Knee extension moment increased in males (0.76) and females (0.48) with an overall effect size of 0.64, but no change in peak abduction moment. Peak Hip extension moment was significant in males (0.58) and overall (0.51), with no changes in internal rotation or adduction moments. Peak vertical ground reaction force showed no significant changes for either gender.
conclusionsFatigue alters knee biomechanics in males, raising ACL injury risk, and both genders show increased hip and ankle loads post-fatigue. These results suggest the need for gender-specific fatigue management strategies to mitigate ACL injury risk and call for further research into prevention mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.