ArticlePloS one2025
Frequency and predictors of depression and anxiety in chronic illnesses: A multi disease study across non-communicable and communicable diseases.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- Factors associated with depression among tuberculosis patients with HIV co-infection in rural community Thailand.BMC psychology · 2026Article
- Article
- Effects of Aquatic Exercise on Sleep Quality in Patients with Chronic Diseases: A Meta-Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Priority of nutrition and exercise in depression management: triangulating mini-review of past and recent evidence with clinical practice guidelines.Journal of health, population, and nutrition · 2025Review
- Correlation Between Serum Testosterone Levels and Erectile Dysfunction Severity in Pakistani Men Aged 40-65 Years.Cureus · 2025Article
- Prevalence of mental health disorders and their association with chronic physical diseases in Kuwait.Frontiers in psychiatry · 2025Article
- Assessment of depression and anxiety in Tunisian patients with chronic diseases: impact on quality of life and medication adherence.Frontiers in psychiatry · 2025Article
- Factors influencing mental health and oral health-related quality of life in population with recurrent aphthous stomatitis: a cross-sectional study.Frontiers in oral health · 2025Article
- Understanding the Triple Burden of HIV, Noncommunicable Diseases, and Mental Health Conditions Among Female Sex Workers With HIV in the Dominican Republic.Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression and anxiety are among the most common mental health conditions globally that impact the lifestyle of affected individuals. Mental conditions and chronic diseases are linked to each other bidirectionally. Depression and anxiety with comorbid chronic conditions are often neglected or under-screened and possess challenges in treatment. This study aimed to know the frequency and determinants of depression and anxiety along with the severity level among common chronic communicable and non-communicable diseases.
methodsWe enrolled 200 healthy controls and 800 cases with equal number (n = 400) of patients with communicable and non-communicable diseases. Depression and anxiety were screened through Hamilton's rating scale for depression and anxiety separately. We also measured the determinants of severe depression among patients with chronic diseases. Data was analyzed through SPSS version 23.
resultsWe found higher frequency of depression (31% vs 11%; p=<0.001) and anxiety (13.25% vs 6%; p = 0.021) among cases as compared to healthy controls respectively. We found higher levels of depression among participants with non-communicable diseases as compared to communicable diseases (37.25% vs 24.75%; p < 0.05) respectively. Moreover, there was a higher frequency of anxiety in participants with communicable diseases as compared to those with non-communicable diseases, but the difference was non-significant (14% vs 12.5% p = 0.081). Among non-communicable diseases the highest percentage was found among individuals with cancer (67%), followed by diabetes (38%), cardiovascular diseases (33%) and respiratory disorders (11%). Among participants with communicable diseases, the highest percentage of depression was found in patients with Tuberculosis (29%) followed by HIV/AIDS (28%), Long COVID-19 (25%) and Hepatitis B/C (17%).
conclusionThere is a significantly higher percentage of depression and anxiety among participants with chronic diseases. It calls for a comprehensive approach to patient care that incorporates mental health as a fundamental aspect of the treatment and management of chronic diseases. Understanding the predictors of severe depression across different chronic conditions helps in stratifying patients who may benefit most from integrated psychiatric and psychological interventions.
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