Evidence map›Paper›PMID 40333909›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis, Evaluation of Biological Activity, and Structure-Activity Relationships of New Amidrazone Derivatives Containing Cyclohex-1-ene-1-Carboxylic Acid.

Renata Paprocka, Jolanta Kutkowska, Ewelina Paczkowska, Godwin Munroe Mwaura, Andrzej Eljaszewicz, Anna Helmin-Basa

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Renata PaprockaDepartment of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, Poland.ORCID 0000-0003-1217-879X
Jolanta KutkowskaDepartment of Genetics and Microbiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka Str. 19, 20-033 Lublin, Poland.ORCID 0000-0002-3307-591X
Ewelina PaczkowskaDepartment of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, M. Curie-Sklodowska Str. 9, 85-094 Bydgoszcz, Poland.
Godwin Munroe MwauraDepartment of Pharmaceutical Chemistry, Pharmaceutics and Pharmacognosy, Faculty of Health Sciences, University of Nairobi, KNH, Nairobi P.O. Box 2149-00202, Kenya.ORCID 0000-0001-6703-0368
Andrzej EljaszewiczCentre of Regenerative Medicine, Medical University of Bialystok, Waszyngtona 15 B, 15-269 Bialystok, Poland.ORCID 0000-0002-8980-1474
Anna Helmin-BasaDepartment of Immunology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, M. Curie-Sklodowska Str. 9, 85-094 Bydgoszcz, Poland.

Funding

Nicolaus Copernicus University IDUB DEBIUTY4 Renata Paprocka
6 · The paper itself

Abstract

In recent years, the incidence of acute and chronic inflammatory diseases has increased significantly worldwide, intensifying the search for new therapeutic agents, especially anti-inflammatory drugs. Therefore, the aim of this work was to synthesize, biologically assess, and explore the structure-activity relationships of new compounds containing the cyclohex-1-ene-1-carboxylic acid moiety. Six new derivatives,

Indexed as

Anti-Infective AgentsCarboxylic AcidsAnti-Bacterial AgentsAnti-Inflammatory AgentsBacteriaCandida albicansCell ProliferationCytokinesHumansLeukocytes, MononuclearMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsCarboxylic AcidsCytokinesamidrazonesantibacterialanti-inflammatoryantiproliferativecyclohexenecytokinesstructure–activity relationships

Identifiers

PMID40333909
PMCPMC12029444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.