Evidence map›Paper›PMID 40333899›Full record

ArticleMolecules (Basel, Switzerland)2025

Development of Fucoxanthin-Enriched Yogurt Using Nanoliposomal Carriers: A Strategy for Functional Dairy Products with Antioxidant and Erythroprotective Benefits.

Miguel Ángel Robles-García, Carmen Lizette Del-Toro-Sánchez, Germán Limón-Vargas, Melesio Gutiérrez-Lomelí, María Guadalupe Avila-Novoa, Fridha Viridiana Villalpando-Vargas, Brenda Vega-Ruiz, Ariadna Thalía Bernal-Mercado, Rey David Iturralde-García, Abril Ivett Priscilla Gómez-Guzman and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. NanoencapsulatedMolecules (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Miguel Ángel Robles-GarcíaDepartment of Medical and Life Sciences, Cienega University Center (CUCIÉNEGA), University of Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, JA, Mexico.ORCID 0000-0002-6379-5088
Carmen Lizette Del-Toro-SánchezDepartment of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, SO, Mexico.ORCID 0000-0001-7029-7741
Germán Limón-VargasDepartment of Medical and Life Sciences, Cienega University Center (CUCIÉNEGA), University of Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, JA, Mexico.
Melesio Gutiérrez-LomelíDepartment of Medical and Life Sciences, Cienega University Center (CUCIÉNEGA), University of Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, JA, Mexico.ORCID 0000-0001-6014-4602
María Guadalupe Avila-NovoaDepartment of Medical and Life Sciences, Cienega University Center (CUCIÉNEGA), University of Guadalajara, Av. Universidad 1115, Lindavista, Ocotlán 47820, JA, Mexico.
Fridha Viridiana Villalpando-VargasDepartment of Health Sciences, University Center of the Valleys (CUVALLE), University of Guadalajara, Carr. a Guadalajara Km. 45.5, Ameca 46600, JA, Mexico.
Brenda Vega-RuizDepartment of Health Sciences, University Center of the Valleys (CUVALLE), University of Guadalajara, Carr. a Guadalajara Km. 45.5, Ameca 46600, JA, Mexico.ORCID 0000-0003-1005-3117
Ariadna Thalía Bernal-MercadoDepartment of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, SO, Mexico.ORCID 0000-0002-7045-8637
Rey David Iturralde-GarcíaDepartment of Research and Postgraduate in Food, University of Sonora, Blvd Luis Encinas y Rosales S/N, Col. Centro, Hermosillo 83000, SO, Mexico.ORCID 0000-0001-8027-1529
Abril Ivett Priscilla Gómez-GuzmanDepartment of Health Sciences, University Center of the Valleys (CUVALLE), University of Guadalajara, Carr. a Guadalajara Km. 45.5, Ameca 46600, JA, Mexico.
Ernesto Ramírez-BrionesDepartment of Applied Ecology, University Center for Biological and Agricultural Sciences (CUCBA), University of Guadalajara, Periférico Norte N° 799 Núcleo Universitario, C. Prol. Belenes, Zapopan 45100, JA, Mexico.ORCID 0000-0002-1428-2542
Reyna Guadalupe López-BerrellezDepartment of Health Sciences, University Center of the Valleys (CUVALLE), University of Guadalajara, Carr. a Guadalajara Km. 45.5, Ameca 46600, JA, Mexico.
Ricardo Iván González-VegaDepartment of Health Sciences, University Center of the Valleys (CUVALLE), University of Guadalajara, Carr. a Guadalajara Km. 45.5, Ameca 46600, JA, Mexico.ORCID 0000-0002-4002-5902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In pursuing functional foods that promote health, nanoliposomal carriers have been used to enhance the stability and functionality of dairy products such as yogurt, promising therapeutic benefits. This study aimed to evaluate the impact of fucoxanthin-loaded nanoliposomes in yogurt on its antioxidant, physicochemical, and rheological properties under cold storage (21 days). Fucoxanthin-loaded nanoliposomes were prepared using the ultrasonic film dispersion technique and added at concentrations of 0%, 5%, and 10% in the yogurt (Y-C, Y-FXN-5, Y-FXN-10). Homogeneous and uniform nanoliposomes (98.28 nm) were obtained, preserving their integrity and functionality and ensuring the prolonged release and bioavailability of fucoxanthin. Y-FXN-10 maintained the highest antioxidant activity according to the DPPH (52.96%), ABTS (97.97%), and FRAP (3.16 mmol ET/g) methods. This formulation exhibited enhanced erythroprotective potential, inhibiting hemolysis, photohemolysis, and heat-induced hemolysis. However, viscosity and firmness decreased, affecting the texture and appearance. Sensory properties such as the color, flavor, aftertaste, texture, and overall acceptance improved with the 10% fucoxanthin-enriched yogurt formulation. These results suggest that nanoliposomes are suitable for carrying fucoxanthin. Their incorporation into food matrices is critical to developing functional foods. Regulatory approvals and consumer perceptions regarding nanotechnology-based products must be addressed, emphasizing their safety and health benefits.

Indexed as

AntioxidantsLiposomesNanoparticlesXanthophyllsYogurtDrug CarriersFunctional FoodHemolysisHumansRheologyViscosityAntioxidantsDrug CarriersfucoxanthinLiposomesXanthophyllsenriched yogurt formulationfucoxanthin-loaded nanoliposomesfunctional foods

Identifiers

PMID40333899
PMCPMC12029523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.