ArticlePloS one2025
Global trends and patterns in cardiovascular disease burden attributable to low physical activity: A systematic analysis for Global Burden of Disease Study from 1990 to 2021.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of mHealth Interventions on Physical Activity and Sedentary Behavior Among Office Workers: A Systematic Review and Meta-analysis.Journal of occupational rehabilitation · 2026Pooled it
- Global and regional burden of cardiovascular diseases due to low physical activity from 1990 to 2021 and projections to 2045: a joinpoint regression and age-period-cohort analysis based on GBD 2021.Internal and emergency medicine · 2026Article
- Global, Regional, and National Burden of Breast Cancer Attributable to Low Physical Activity in Women of Reproductive Age: Historical Trends from 1990 to 2021 and Projections to 2035.Archives of Iranian medicine · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThis study analyzes the global burden of cardiovascular diseases (CVD) related to low physical activity from 1990 to 2021, focusing on spatiotemporal changes.
methodUsing data from the GBD study, we examined trends in CVD burden linked to low physical activity, including mortality counts, disability-adjusted life years (DALYs), age-standardized mortality rates (ASMR), and age-standardized disability rates (ASDR). Decomposition analysis was used to identify key drivers of these changes, and frontier analysis visualized each country's potential to reduce the burden. An autoregressive integrated moving average model was used to forecast the burden from 2022 to 2036.
resultsIn 2021, approximately 370,000 deaths globally were attributed to CVD due to low physical activity. The ASMR and ASDR for CVD were 4.53 per 100,000 (95% uncertainty interval: 1.52 to 8.05) and 85.95 (95% UI: 35.25 to 140.65), respectively. From 1990 to 2021, the global burden increased, particularly in regions with a middle socio-demographic index, driven by aging populations and population growth. The ASMR is projected to decrease to 3.49 per 100,000 by 2036.
conclusionsLow physical activity is a major contributor to CVD-related mortality and disability worldwide. Public health interventions aimed at increasing physical activity, especially in regions with rising burdens, are essential to reduce the global CVD burden.
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