ArticleMolecules (Basel, Switzerland)2025
The Properties of the Monolayers of Sorbitan Lipids as Informative Factors on the Hydrophilic-Lipophilic Balance Value of Their Mixtures, Proposed for Dermatological Applications.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The effect of sucrose palmitate characteristics as a surfactant on the physical stability of red palm oil submicroemulsions.Journal of advanced pharmaceutical technology & researchArticle
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Authors and funding
5 authors.
Funding
Abstract
This study investigates the correlation between the hydrophilic-lipophilic balance (HLB) values and the π-A isotherm parameters of surfactant monolayers composed of sorbitan esters, specifically sorbitan monopalmitate, sorbitan tristearate, sorbitan monooleate, and sorbitan sesquioleate. The surfactant mixtures were prepared, and their π-A isotherms were recorded. The HLB values calculated for each mixture were in the range 2.10-6.70. The HLB values were compared to compression parameters, including the ratios of the slopes and the ratios of the intercepts, which were between 0.19 and 4.00 and between 0.64 and 1.77, respectively, across the monolayer compression stages. The findings indicate a significant relationship between HLB values and isotherm parameters, particularly for systems with sorbitan monooleate and sorbitan sesquioleate. A value of determination coefficient of 0.95 was found for the linear equation representing the slope ratios as a function of HLB, whereas the intercept ratios, as a linear function of HLB, gave a lower value of 0.71. The results allow for the use of the π-A Langmuir isotherm to experimentally estimate the value of the HLB in mixtures of the sorbitol esters of fatty acids, whose value is an important parameter in the selection of optimized topical and transdermal formulations, highlighting the specific formulations that enhance active substance delivery while minimizing skin irritation potential.
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Registered trials
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