ArticleMolecules (Basel, Switzerland)2025
Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide Ring Opening.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A solvent-free, microwave-assisted approach for the ring-opening reactions of phenyl glycidyl ether with a series of commercially available imidazoles and pyrazoles is described. Microwave irradiation allows reactions to proceed rapidly. This straightforward approach efficiently generated adducts with competitive yields compared to traditional methods that use conventional heating or organic solvents. This technique is particularly suited for high-throughput screening in drug discovery, offering a significant reduction in time and resource consumption.
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