Evidence map›Paper›PMID 40333757›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Hdac1 as an early determinant of intermediate-exhausted CD8

Wei Hu, Shengen Shawn Hu, Shaoqi Zhu, Weiqun Peng, Vladimir P Badovinac, Chongzhi Zang, Xudong Zhao, Hai-Hui Xue

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Exhausted CD8Nature immunology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei HuCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ 07110.ORCID 0000-0003-3031-5938
Shengen Shawn HuDepartment of Genome Sciences and University of Virginia Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22908.
Shaoqi ZhuDepartment of Physics, The George Washington University, Washington, DC 20052.ORCID 0000-0001-9509-3526
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC 20052.
Vladimir P BadovinacDepartment of Pathology, University of Iowa, Iowa City, IA 52242.ORCID 0000-0003-3180-2439
Chongzhi ZangDepartment of Genome Sciences and University of Virginia Comprehensive Cancer Center, University of Virginia, Charlottesville, VA 22908.ORCID 0000-0003-4812-3627
Xudong ZhaoDepartment of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ 07110.ORCID 0000-0002-9163-7669

Funding

Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Memory CD8 T cell localization and protection from influenzaR01AI114543 · NIAID · UNIVERSITY OF IOWA · PI BADOVINAC, VLADIMIR P, HARTY, JOHN T · 2015 to 2024
$4.4M
ID3 regulation of tissue-infiltrating T cells mediating graft-versus-host disease and leukemia rejectionR01CA290808 · NCI · HACKENSACK UNIVERSITY MEDICAL CENTER · PI Hai-Hui Xue, YI ZHANG · 2024 to 2026
$2.2M
BLRD VA I01 BX005771HHS | NIH | National Cancer Institute (NCI) CA290808HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI112579HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI114543HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI121080MOST | National Key Research and Development Program of China (NKPs) 2022YFE 0131800NCI NIH HHS R01 CA290808NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI114543NIAID NIH HHS R01 AI121080U.S. Department of Veterans Affairs (VA) BX005771
6 · The paper itself

Abstract

The exhausted CD8

Indexed as

CD8-Positive T-LymphocytesHistone Deacetylase 1Lymphocytic ChoriomeningitisPersistent InfectionAnimalsCell DifferentiationCX3C Chemokine Receptor 1Hepatocyte Nuclear Factor 1-alphaKruppel-Like Transcription FactorsLymphocytic choriomeningitis virusMiceMice, Inbred C57BLCX3C Chemokine Receptor 1Hdac1 protein, mouseHepatocyte Nuclear Factor 1-alphaHistone Deacetylase 1Hnf1a protein, mouseKlf2 protein, mouseKruppel-Like Transcription Factorsepigentic regulationhistone deacetylaseT cell exhaustiontransitory state

Identifiers

PMID40333757
PMCPMC12088444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.