Evidence map›Paper›PMID 40333753›Full record

ArticleMolecules (Basel, Switzerland)2025

6-Chlorocoumarin Conjugates with Nucleobases and Nucleosides as Potent Anti-Hepatitis C Virus Agents.

Shu-Yu Lin, Wen-Chieh Huang, Shwu-Chen Tsay, Johan Neyts, Pieter Leyssen, Chun-Cheng Lin, Kuo Chu Hwang, Jia-Cherng Horng, Jih Ru Hwu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shu-Yu LinInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350401, Taiwan.ORCID 0009-0001-4165-7602
Wen-Chieh HuangInstitute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350401, Taiwan.ORCID 0000-0001-9599-7613
Shwu-Chen TsayDepartment of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0003-0585-3419
Johan NeytsRega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.ORCID 0000-0002-0033-7514
Pieter LeyssenRega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Chun-Cheng LinDepartment of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-2323-0920
Kuo Chu HwangDepartment of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0003-1814-9869
Jia-Cherng HorngDepartment of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-9936-5338
Jih Ru HwuDepartment of Chemistry and Frontier Research Center on Fundamental & Applied Sciences of Matters, National Tsing Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-9225-8484

Funding

National Health Research Institutes, Taiwan BP-114-PP-04National Health Research Institutes, Taiwan BP-114-SP-02National Science and Technology Council, Taiwan 112-2113-M-007-001National Science and Technology Council, Taiwan 14-2113-M-400-002
6 · The paper itself

Abstract

On the basis of a "chemo-combination strategy", (6-chloro)coumarin was incorporated to purines and pyrimidines, as well as their corresponding nucleosides, with a -SCH

Indexed as

Antiviral AgentsCoumarinsHepacivirusNucleosidesCell Line, TumorHumansMolecular StructurePurinesStructure-Activity RelationshipVirus ReplicationAntiviral AgentsCoumarinsNucleosidesPurinescoumarinhepatitis C virusmercaptopurinenucleosidesstructure–activity relationship

Identifiers

PMID40333753
PMCPMC12029179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.