Evidence map›Paper›PMID 40333663›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis of the Pentasaccharide Unit of the

Uzoamaka Clara Bokolo, Ravindika Dissanayake, Samir Ghosh, Shadia Nada, Babatunde S Obadawo, Erin G Prestwich, Katherine A Wall, Steven J Sucheck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Uzoamaka Clara BokoloDepartment of Chemistry and Biochemistry, The University of Toledo, 2801 W. Bancroft Street, Toledo, OH 43606, USA.ORCID 0009-0007-4085-6427
Ravindika DissanayakeDepartment of Medicinal and Biological Chemistry, The University of Toledo, 3000 Arlington Ave., Toledo, OH 43614, USA.
Samir GhoshDepartment of Chemistry and Biochemistry, The University of Toledo, 2801 W. Bancroft Street, Toledo, OH 43606, USA.ORCID 0000-0002-7515-6726
Shadia NadaDepartment of Medicinal and Biological Chemistry, The University of Toledo, 3000 Arlington Ave., Toledo, OH 43614, USA.
Babatunde S ObadawoDepartment of Chemistry and Biochemistry, The University of Toledo, 2801 W. Bancroft Street, Toledo, OH 43606, USA.ORCID 0000-0001-7292-6564
Erin G PrestwichDepartment of Medicinal and Biological Chemistry, The University of Toledo, 3000 Arlington Ave., Toledo, OH 43614, USA.
Katherine A WallDepartment of Medicinal and Biological Chemistry, The University of Toledo, 3000 Arlington Ave., Toledo, OH 43614, USA.ORCID 0000-0002-1150-4736
Steven J SucheckDepartment of Chemistry and Biochemistry, The University of Toledo, 2801 W. Bancroft Street, Toledo, OH 43606, USA.ORCID 0000-0003-0082-3827

Funding

Understanding trehalose synthesis and utilization in mycobacteriaR01AI105084 · NIAID · UNIVERSITY OF TOLEDO · PI RONNING, DONALD R, SUCHECK, STEVEN · 2013 to 2022
$3.7M
Methods to synthesize oligosaccharide-fusion protein conjugates and enhancement of their antigenicityR01AI148570 · NIAID · UNIVERSITY OF TOLEDO · PI SUCHECK, STEVEN, WALL, KATHERINE A · 2020 to 2024
$2.3M
Mechanistic tRNA modification affects to agingR21AG091047 · NIA · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI PRESTWICH, ERIN G, SENYO, SAMUEL · 2025 to 2025
$431k
NIAID NIH HHS R01 AI105084NIAID NIH HHS R01 AI148570NIA NIH HHS R21 AG091047NIH HHS AI148570
6 · The paper itself

Abstract

Oligosaccharides and glycoconjugates play essential roles in various biological processes such as cellular recognition and signaling, and thus have attracted tremendous attention in the synthetic and biological communities over the past few decades. Contributing to this field, we have achieved the synthesis of the aminoxyglycoside pentasaccharide subunit of

Indexed as

Bacterial ProteinsOligosaccharidesPolysaccharides, BacterialPseudomonas aeruginosaAnimalsAntibodies, BacterialVaccines, ConjugateAntibodies, BacterialBacterial ProteinsCRM197 (non-toxic variant of diphtheria toxin)OligosaccharidesPolysaccharides, BacterialVaccines, Conjugatecarbohydrate vaccineCRM197Pseudomonas aeruginosaPsl exopolysaccharideQS21β-mannoside

Identifiers

PMID40333663
PMCPMC12029197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.