Evidence map›Paper›PMID 40333570›Full record

ArticleMolecules (Basel, Switzerland)2025

Enhancing the Solubility of Isoconazole Nitrate Using Methyl-β-Cyclodextrin: Formulation and Characterization of Inclusion Complexes.

Tarek Alloush, Gülsel Yurtdaş Kırımlıoğlu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tarek AlloushDepartment of Pharmaceutical Technology, Institute of Health Sciences, Istanbul University, Istanbul 34126, Türkiye.ORCID 0009-0007-9501-6863
Gülsel Yurtdaş KırımlıoğluDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Türkiye.ORCID 0000-0001-8897-0885

Funding

Anadolu University 1907S132
6 · The paper itself

Abstract

Isoconazole nitrate (ISN) is a broad-spectrum antifungal agent whose therapeutic potential is limited by poor aqueous solubility and low bioavailability. This study aimed to enhance the solubility and physicochemical properties of ISN through the formation of inclusion complexes with methyl-β-cyclodextrin (M-β-CD) using freeze-drying (FD) and spray-drying (SD) methods. The prepared inclusion complexes were comprehensively characterized by high-performance liquid chromatography (HPLC), phase solubility analysis, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and proton nuclear magnetic resonance (

Indexed as

Antifungal Agentsbeta-CyclodextrinsMiconazoleCalorimetry, Differential ScanningDrug CompoundingFreeze DryingSolubilitySpectroscopy, Fourier Transform InfraredAntifungal Agentsbeta-Cyclodextrinsmethyl-beta-cyclodextrinMiconazolefreeze-dryinginclusion complexisoconazole nitratemethyl-β-cyclodextrinphase solubilityspray-drying

Identifiers

PMID40333570
PMCPMC12029313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.