N,N- and N,O-Bidentate-Chelation-Assisted Alkenyl C-H Functionalization.

Yawei Zhang, Chengxing Peng, Xiaoli Li, Xiuying Liu, Liyuan Ding, Guofu Zhong, Jian Zhang

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Yawei ZhangSchool of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

Chengxing PengKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Xiaoli LiKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Xiuying LiuKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Liyuan DingKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Guofu ZhongSchool of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.

Jian ZhangKey Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Zhejiang Key Laboratory of Organosilicon Material Technology, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0001-8734-3003

Funding

National Natural Science Foundation of China 22278103, 21502037

6 · The paper itself

Abstract

Chelation-assisted olefinic C-H functionalization has been demonstrated to be a powerful method of constructing multi-substituted alkenes from simpler ones. This strategy produces complex alkenes in a regio- and stereoselective manner, followed by C-H endo- and exo-cyclometallation. Among the various directing groups developed, N,N- and N,O-bidentate directing groups are the most widely used to selectively promote C-H functionalization due to their fine, tunable, and reversible coordination with the metal center. In this review, we discuss various N,N- and N,O-bidentate directing group-assisted olefinic C-H bond functionalization reactions, including alkenylation, alkylation, arylation, thiolation, silylation, halogenation, and cyclization.

Indexed as

alkenebidentate chelation assistanceC–H activationdirecting group

Identifiers

PMID40333556

DOI10.3390/molecules30081669

PMCPMC12029784

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