Evidence map›Paper›PMID 40333334›Full record

ArticleVaccines2025

Adenosine 2B Receptor Signaling Impairs Vaccine-Mediated Protection Against Pneumococcal Infection in Young Hosts by Blunting Neutrophil Killing of Antibody-Opsonized Bacteria.

Shaunna R Simmons, Alexsandra P Lenhard, Michael C Battaglia, Elsa N Bou Ghanem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shaunna R SimmonsDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0002-2179-3631
Alexsandra P LenhardDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Michael C BattagliaDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0003-4809-7991
Elsa N Bou GhanemDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0002-8936-1341

Funding

The role of neutrophils in the age-driven decline in anti-pneumococcal vaccine responsesR01AG068568 · NIA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI BOU GHANEM, ELSA · 2021 to 2025
$2.0M
The role of A1 adenosine receptor signaling in the decline of S. pneumoniae killing by neutrophils in vaccinated aged hostsF31AI169889 · NIAID · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIMMONS, SHAUNNA · 2023 to 2025
$83k
National Institute of Health F31 AI169889-01A1National Institute of Health R01 AG068568-01A1NIAID NIH HHS F31 AI169889NIA NIH HHS R01 AG068568
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingextracellular adenosinePMNspneumococcal conjugate vaccine

Identifiers

PMID40333334
PMCPMC12031446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.